Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol USP9Y contributors: mct - updated : 05-11-2012
HGNC name ubiquitin specific protease 9, Y chromosome (fat facets-like Drosophila)
HGNC id 12633
Corresponding disease
AZFA nonobstructive spermatogenic failure
Location Yq11.23      Physical location : 14.813.159 - 14.972.768
Synonym name
  • ubiquitin thiolesterase FAF-Y
  • ubiquitin-specific processing protease FAF-Y
  • azoospermia factor 1
  • Synonym symbol(s) DFFRY, SPGFY2
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 158.00 kb     46 Exon(s)    single Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC392590 Y similar to RCC1-like ASSP6 Yq11.22 argininosuccinate synthetase pseudogene 6 ADLICANP Yq11.21 adlican pseudogene RPS24P1 Yq11.23 ribosomal protein S24 pseudogene 1 LOC386726 ARSEP Yq11.2 arylsulfatase E pseudogene ARSDP Yq11.2 arylsulfatase D pseudogene GYG2P Yq11.23 glycogenin 2 pseudogene APXLP Yq11.23 apical protein-like (Xenopus laevis) pseudogene LOC359791 Yq11.1 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa pseudogene TTTY15 Yq11.1 testis-specific transcript, Y-linked 15 USP9Y Yq11.23 ubiquitin specific protease 9, Y chromosome (fat facets-like Drosophila) CDY4P Yq11.2 chromodomain protein, Y-linked 4 pseudogene DDX3Y Yq11.11-q11.21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked CASKP Yq11 calcium/calmodulin-dependent serine protein kinase (MAGUK family) pseudogene SFPQP Yq11.23 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) pseudogene UTY Yq11.1-q11.21 ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome PSMA6P Yq11.1 proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene TMSB4Y Yq11.1-q11.22 thymosin, beta 4, Y chromosome LOC360022 Yq11 PC4 and SFRS1 interacting protein 2 pseudogene KALP Yq11.21 Kallmann syndrome sequence pseudogene VCY Yq11.21 variable charge, Y chromosome NLGN4Y Yq11.21 neuroligin 4, Y linked LOC359793 Yq11.21 hypothetical protein FLJ10842 pseudogene HCP46 Yq11.221 cytochrome c, somatic pseudogene
    regionally located in a AZF deleted region
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis   
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text pregnancy, in a wide range of tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five highly conserved domains
  • domains I, II and III containing the expected catalytic triad Cys, Asp, His which defines cysteine proteases
  • HOMOLOGY
    interspecies homolog to Drosophila developmental gene fat facets related on the Y
    Homologene
    FAMILY deubiquitin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ubiquitin specific protease involved in spermatogenesis
  • may stabilize a specific target protein that is important for male germ cell development
  • during human spermatogenesis, is more likely a fine tuner that improves efficiency, rather than a provider of an essential function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AZFA
    Susceptibility
    Variant & Polymorphism
    Candidate gene complete deletion of USP9Y is compatible with normal spermatogenesis (Luddi,09)suggesting that USP9Y does not play a key role in male reproduction
    Marker
    Therapy target
    ANIMAL & CELL MODELS