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FLASH GENE
Symbol USP9Y contributors: mct - updated : 05-11-2012
HGNC name ubiquitin specific protease 9, Y chromosome (fat facets-like Drosophila)
HGNC id 12633
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivemale systemtestis   
 male systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text pregnancy, in a wide range of tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five highly conserved domains
  • domains I, II and III containing the expected catalytic triad Cys, Asp, His which defines cysteine proteases
  • HOMOLOGY
    interspecies homolog to Drosophila developmental gene fat facets related on the Y
    Homologene
    FAMILY deubiquitin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ubiquitin specific protease involved in spermatogenesis
  • may stabilize a specific target protein that is important for male germ cell development
  • during human spermatogenesis, is more likely a fine tuner that improves efficiency, rather than a provider of an essential function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AZFA
    Susceptibility
    Variant & Polymorphism
    Candidate gene complete deletion of USP9Y is compatible with normal spermatogenesis (Luddi,09)suggesting that USP9Y does not play a key role in male reproduction
    Marker
    Therapy target
    ANIMAL & CELL MODELS