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FLASH GENE
Symbol UNC93B1 contributors: mct - updated : 24-10-2013
HGNC name unc-93 homolog B1 (C. elegans)
HGNC id 13481
Corresponding disease
HSE herpes simplex virus-1 (HSV-1) encephalitis
Location 11q13.2      Physical location : 67.758.574 - 67.771.593
Synonym name
  • unc-93 related protein
  • unc93 (C.elegans) homolog B
  • protein unc-93 homolog B1
  • Synonym symbol(s) UNC93, MGC126617, UNC93B, Unc-93B1, IIAE1
    DNA
    TYPE functioning gene
    STRUCTURE 13.02 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • promoter region contains binding sites for poly(I:C)- and type I interferon-inducible regulatory elements
  • MAPPING cloned Y linked N status provisional
    Physical map
    CABP2 11q13.1 calcium binding protein 2 GSTP1 11q13.3 glutathione S-transferase pi FLJ90834 11q13.1 hypothetical protein FLJ90834 NDUFV1 11q13 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa LOC390213 11 similar to Double C2, gamma NUDT8 11q13.1 nudix (nucleoside diphosphate linked moiety X)-type motif 8 TBX10 11q13 T-box 10 ACY-3 11q13.1 aspartoacylase-3 ALDH3B2 11q13 aldehyde dehydrogenase 3 family, member B2 RPL37P2 11q13 ribosomal protein L37 pseudogene 2 LOC132740 11q13.1 similar to unc-93 homolog B1; unc93 (C.elegans) homolog B; unc-93 related protein LOC390215 11 similar to seven transmembrane helix receptor OR7E11P 11q11 olfactory receptor, family 7, subfamily E, member 11 pseudogene LOC390216 11 similar to mannosyltransferase LOC158490 11q13.1 similar to hypothetical protein FLJ10661 LOC387785 11 LOC387785 LOC390217 11 similar to chromosome 11 open reading frame2; chromosome  11 open reading frame2 LOC341128 11q13.1 similar to seven transmembrane helix receptor UNC93B1 11q13 unc-93 homolog B1 (C. elegans) ALDH3B1 11q13 aldehyde dehydrogenase 3 family, member B1 NDUFS8 11q13 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) TCIRG1 11q13.4-q13.5 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3 CHK 11q13.1 choline kinase CGI-85 11q13 choline kinase C11orf24 11q13 chromosome 11 open reading frame 24 LRP5 11q13 low density lipoprotein receptor-related protein 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2334 66 597 - 2002 1186722
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix moderately
     male systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple potential membrane-spanning domains
  • twelve transmembrane domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Unc93b1 (91.1 pc)
    homolog to murine Unc93b1 (90.9 pc)
    Homologene
    FAMILY
  • UNC93B-related gene family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text multi-pass membrane protein
    basic FUNCTION
  • delivering the nucleotide-sensing receptors TLR7 and TLR9 from the endoplasmic reticulum (ER) to the endolysosomes
  • can control the functional pool of TLR9 by regulating exit from the ER
  • with CNPY3, and HSP90B21, play a role in TLR localisation
  • critical role for UNC93B1 on induction of IL12/IFNG production as well as autonomous control of Toxoplasma replication by macrophages
  • upon activation, TLR7 and 9 are transported from the endoplasmic reticulum (ER) to endolysosomes for nucleic acid sensing by an ER-resident protein, UNC93B1
  • participates in intracellular trafficking and signaling for all nucleotide-sensing TLRs, but the mode of regulation of TLR localization differs for each TLR
  • involved in Toll-like receptor activation
  • UNC93B1 expression is required for TLR3 cleavage and signaling
  • multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes
  • essential for trafficking of endosomal TLRs from the endoplasmic reticulum to endosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking
  • essential for intracellular trafficking and endolysosomal targeting of TLR7 and TLR9
  • is required for processing by transporting TLR3 through the Golgi complex and to the endosomes
  • TLR3 is an important regulator of UNC93B1 that in turn governs the responsiveness of all nucleic acid-sensing (NAS) Toll-like receptors (TLRs)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSE
    Susceptibility to childhood herpes simplex encephalitis
    Variant & Polymorphism other mutations associated with childhood herpes simplex encephalitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • may be involved in the regulation or coordination of muscle contraction in the worm