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FLASH GENE
Symbol UNC93B1 contributors: mct - updated : 24-10-2015
HGNC name unc-93 homolog B1 (C. elegans)
HGNC id 13481
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2334 66 597 - 2002 1186722
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Lymphoid/Immunelymph node   highly
 tonsils   highly
Nervousbrain    
Reproductivefemale systemuteruscervix moderately
 male systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymhoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple potential membrane-spanning domains
  • twelve transmembrane domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Unc93b1 (91.1 pc)
    homolog to murine Unc93b1 (90.9 pc)
    Homologene
    FAMILY
  • UNC93B-related gene family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text multi-pass membrane protein
    basic FUNCTION
  • delivering the nucleotide-sensing receptors TLR7 and TLR9 from the endoplasmic reticulum (ER) to the endolysosomes
  • can control the functional pool of TLR9 by regulating exit from the ER
  • with CNPY3, and HSP90B21, play a role in TLR localisation
  • critical role for UNC93B1 on induction of IL12/IFNG production as well as autonomous control of Toxoplasma replication by macrophages
  • upon activation, TLR7 and 9 are transported from the endoplasmic reticulum (ER) to endolysosomes for nucleic acid sensing by an ER-resident protein, UNC93B1
  • participates in intracellular trafficking and signaling for all nucleotide-sensing TLRs, but the mode of regulation of TLR localization differs for each TLR
  • involved in Toll-like receptor activation
  • UNC93B1 expression is required for TLR3 cleavage and signaling
  • multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes
  • essential for trafficking of endosomal TLRs from the endoplasmic reticulum to endosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking
  • essential for intracellular trafficking and endolysosomal targeting of TLR7 and TLR9
  • is required for processing by transporting TLR3 through the Golgi complex and to the endosomes
  • TLR3 is an important regulator of UNC93B1 that in turn governs the responsiveness of all nucleic acid-sensing (NAS) Toll-like receptors (TLRs)
  • to restrict Nucleic acid (NA)-sensing in endolysosomes, TLR7/9 trafficking is tightly controlled by a multiple transmembrane protein UNC93B1
  • upon ligand stimulation, LRRC59 associated with UNC93B1 in a TLR-independent manner, which required signals induced by ligand internalization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSE
    Susceptibility to childhood herpes simplex encephalitis
    Variant & Polymorphism other mutations associated with childhood herpes simplex encephalitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • may be involved in the regulation or coordination of muscle contraction in the worm