basic FUNCTION
| primarily brain-specific phorbol ester receptors, involved in intracellular signaling cascade |
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having a central priming function in synaptic vesicle exocytosis at glutamatergic and GABAergic synapses and a potential role in synaptic plasticity (Yang 2007) |
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presynaptic protein at parallel fiber-Purkinje cell synapses, acting at a similar step of the synaptic vesicle cycle as UNC13A (Augustin 2001) |
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neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release (Augustin 1999) |
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UNC13B and UNC13C limit the ability of UNC13A to regulate calcium-dependent replenishment of readily releasable pool and slow pool to fast pool conversion in central synapses |
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SEPTIN5 has been known for some time as a developmentally down-regulated "inhibitor" of tight coupling, while UNC13C was found only recently to function as a developmentally up-regulated mediator of tight coupling |