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FLASH GENE
Symbol UNC13C contributors: mct/npt - updated : 30-08-2019
HGNC name unc-13 homolog C (C. elegans)
HGNC id 23149
Location 15q21.3      Physical location : 54.305.100 - 54.920.805
Synonym name
  • unc-13-like 3
  • unc-13 homolog C
  • Synonym symbol(s) DKFZp547H074, Munc13-3
    DNA
    TYPE functioning gene
    STRUCTURE 615.71 kb     31 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 8140 - 2214 - Yang (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C2 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • munc-13 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text localized to the synaptic neuropil of the cerebellar molecular layer but is not found in Purkinje cell dendrites (Augustin 2001)
    basic FUNCTION
  • primarily brain-specific phorbol ester receptors, involved in intracellular signaling cascade
  • having a central priming function in synaptic vesicle exocytosis at glutamatergic and GABAergic synapses and a potential role in synaptic plasticity (Yang 2007)
  • presynaptic protein at parallel fiber-Purkinje cell synapses, acting at a similar step of the synaptic vesicle cycle as UNC13A (Augustin 2001)
  • neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release (Augustin 1999)
  • UNC13B and UNC13C limit the ability of UNC13A to regulate calcium-dependent replenishment of readily releasable pool and slow pool to fast pool conversion in central synapses
  • SEPTIN5 has been known for some time as a developmentally down-regulated "inhibitor" of tight coupling, while UNC13C was found only recently to function as a developmentally up-regulated mediator of tight coupling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein with UNC13B, are expressed in a complementary fashion and might act in concert with UNC13A to modulate neurotransmitter release (Augustin 1999)
    cell & other
    REGULATION
    Other regulated by age and dark rearing in the same manner as physiological plasticity during the visual cortical critical period (Yang 2002)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for critical period neuroplasticity in visual cortex (Yang 2007)
    Marker
    Therapy target
    ANIMAL & CELL MODELS