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Nucleotide
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FLASH GENE
Symbol
UCK1
contributors: mct -
updated
: 04-07-2023
HGNC name
uridine-cytidine kinase
HGNC id
14859
FLASH GENE
DNA
RNA
EXPRESSION
PROTEIN
DISORDER
ANIMAL & CELL MODELS
Location
9q34.13
Physical location :
134.399.183 - 134.406.662
Synonym name
cytidine monophosphokinase 1
uridine monophosphokinase 1
Synonym symbol(s)
URK1, FLJ12255, RP11-334J6.5
EC.number
2.7.1.48
DNA
TYPE
functioning gene
STRUCTURE
7.46 kb 7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING
cloned
Y
linked
N
status
provisional
RNA
TRANSCRIPTS
type
messenger
identification
nb exons
type
bp
product
Protein
kDa
AA
specific expression
Year
Pubmed
-
-
-
2700
-
-
ubiquitous
Van Rompay
-
-
-
1800
-
-
skeletal muscle,heart,liver,kidney
Van Rompay
-
-
-
1200
-
-
only placenta
Van Rompay
-
-
-
2000
-
-
only placenta
Van Rompay
NM_001261450
7
-
2135
NP_001248379
-
268
-
2016
27239701
NM_001261451
7
-
2177
NP_001248380
-
282
-
2016
27239701
NM_001318519
7
-
2093
NP_001305448
-
254
-
2016
27239701
NM_001135954
6
-
2067
NP_001129426
-
201
-
2016
27239701
NM_031432
7
-
2162
NP_113620
-
277
-
2016
27239701
EXPRESSION
Type
ubiquitous
expressed in
(based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies
homolog to yeast uck
Homologene
FAMILY
uridine kinase family
CATEGORY
enzyme
SUBCELLULAR LOCALIZATION
intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
involved in the phosphorylation of nucleoside analogs
UCK1, UCK2, play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
purine/pyrimidine
signaling
a component
INTERACTION
DNA
RNA
small molecule
nucleotide,
ATP binding
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS
