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FLASH GENE
Symbol UCK1 contributors: mct - updated : 04-07-2023
HGNC name uridine-cytidine kinase
HGNC id 14859
DNA
TYPE functioning gene
STRUCTURE 7.46 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 2700 - - ubiquitous Van Rompay
- - - 1800 - - skeletal muscle,heart,liver,kidney Van Rompay
- - - 1200 - - only placenta Van Rompay
- - - 2000 - - only placenta Van Rompay
7 - 2135 - 268 - 2016 27239701
7 - 2177 - 282 - 2016 27239701
7 - 2093 - 254 - 2016 27239701
6 - 2067 - 201 - 2016 27239701
7 - 2162 - 277 - 2016 27239701
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast uck
Homologene
FAMILY uridine kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in the phosphorylation of nucleoside analogs
  • UCK1, UCK2, play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS