basic FUNCTION
| RNA polymerase 1, associated transcription factor 1 |
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essential for activation of transcription of 18S and 28S RNA |
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required for the initiation of the transcriptional complex |
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activates RNA polymerase I transcription by stimulating promoter escape |
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with RUNX2, and TLE1 together occupy nucleolar organizing regions (NORs) during mitosis and control histone modifications |
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required for recruiting Pol II to the highly transcribed histone gene clusters and for their optimal expression |
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novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity) |
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is instrumental in the generation of rRNA transcripts (pMID: 28777933) |