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FLASH GENE
Symbol UBTF contributors: mct/npt/pgu - updated : 23-06-2015
HGNC name upstream binding transcription factor, RNA polymerase I
HGNC id 12511
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six DNA binding motifs HMG-box
  • a transactivation domain and several HMG domains that are required for DNA binding and the activation of rDNA transcription
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text colocalizing with BAZ2A, SMARCA5
    basic FUNCTION
  • RNA polymerase 1, associated transcription factor 1
  • essential for activation of transcription of 18S and 28S RNA
  • required for the initiation of the transcriptional complex
  • activates RNA polymerase I transcription by stimulating promoter escape
  • with RUNX2, and TLE1 together occupy nucleolar organizing regions (NORs) during mitosis and control histone modifications
  • required for recruiting Pol II to the highly transcribed histone gene clusters and for their optimal expression
  • novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity)
  • is instrumental in the generation of rRNA transcripts (pMID: 28777933)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a nucleolar remodeling complex (NoRC) with BAZ2A, SMARCA5
  • INTERACTION
    DNA binding to rRNA gene promoter
    RNA
    small molecule
    protein
  • interacting with TCOF1
  • partner of CDKN2A (negatively regulates rRNA transcription and inhibits UBTF transcription factor phosphorylation)
  • TCOF1 associates with upstream binding factor (UBTF) to regulate rRNA gene (rDNA) transcription
  • interacting with RASL11A (co-localizes with UBTF not only at nucleoli in interphase, but also on chromosomes in mitotic cells)
  • CHP -binding protein
  • UTP20 interacts with UBF at the rDNA promoter
  • PHF6 localizes to the nucleolus, directly interacts with upstream binding factor (UBTF), and suppresses ribosomal RNA (rRNA) transcription by affecting the protein level of UBTF
  • UBTF, a transcription factor required for the expression of ribosomal RNAs, is a major PHF6-associated protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CONDBA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS