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FLASH GENE
Symbol UBE2V2 contributors: mct - updated : 21-10-2011
HGNC name ubiquitin-conjugating enzyme E2 variant 2
HGNC id 12495
Location 8q11.21      Physical location : 48.920.994 - 48.974.452
Synonym name
  • 1 alpha,25-dihydroxyvitamin D3-inducible
  • enterocyte differentiation promoting factor
  • methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
  • Synonym symbol(s) DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2
    DNA
    TYPE functioning gene
    STRUCTURE 53.46 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D8S519 - UBE2V2 - D8S517 - qter
    Authors Gene Map (98)
    Physical map
    LOC389652 8 similar to asparagine synthetase; glutamine-dependent asparagine synthetase; TS11 cell cycle control protein LOC392215 8 similar to hypothetical protein FLJ90430 MAPK6PS4 8q11.23 similar to hypothetical protein FLJ90430 LOC392216 8 similar to KIAA0565 protein LOC253986 8q11.21 similar to ribosomal protein L10a LOC389654 8 LOC389654 LOC392217 8 similar to Ig lambda light chain leader and V-region KIAA0146 8q11.21 KIAA0146 protein CEBPD 8q11 CCAAT/enhancer binding protein (C/EBP), delta PRKDC 8q11 protein kinase, DNA-activated, catalytic polypeptide MCM4 8q11.2 MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) UBE2V2 8q11.1-q11.21 ubiquitin-conjugating enzyme E2 variant 2 LOC203010 8q11.21 similar to IDI1 protein LOC389655 8 similar to ribosomal protein L29 FLJ11767 8q11.21 hypothetical protein FLJ11767 LOC392218 8 similar to Band 4.1-like protein 5 SNAI2 8q11.1-q11.2 snail homolog 2 (Drosophila) LOC137133 8q11.22 similar to phosphoserine aminotransferase isoform 1 LOC389656 8 LOC389656 SNTG1 8q11.2-q12 syntrophin, gamma 1 HCP22 8q11.22 cytochrome c, somatic pseudogene FLJ25471 8q11.22 hypothetical protein FLJ25471 BTF3P1 8q11.22 basic transcription factor 3, pseudogene 1 LOC115294 8q11.22 similar to hypothetical protein FLJ10883 LOC389657 8 LOC389657 ST18 8q11.21 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) LOC389658 8 similar to RPLK9433 RB1CC1 8p22-q11.23 RB1-inducible coiled-coil 1 GPR7 10q11.2-q21.1 G protein-coupled receptor 7 LOC392219 8 similar to ring finger protein 2 OPRK1 8q11.2 opioid receptor, kappa 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1535 - 145 - 1998 9705497
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines some cancer lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an acidic domain
  • a C terminal basic domain, lacking the critical cysteine residue essential for E2 catalytic activity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in the control of differentiation
  • ubiquitin dependent proteolytic protein
  • UBE2V2 along with its heteromeric partner UBE2N can govern the error-free repair of DNA lesions by catalyzing the formation of lysine 63-linked polyubiquitin chains (K63-polyUb)
  • serves a redundant role in human PCNA polyubiquitination
  • CELLULAR PROCESS cell life, differentiation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with UBE2N (UBE2N-UBE2V2 is required for DNA damage repair but not nuclear factor kappaB (NF-kappaB) activation)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2V2 physical association with Ub is correlated with its ability to promote Lys63-linked Ub chain assembly (
  • interactions between TRIM32 and UBE2V2, and UBE2V1
  • UBE2N is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UBE2V1 or UBE2V2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS