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FLASH GENE

Symbol

TUBGCP4

contributors: mct - updated : 24-09-2012

HGNC name	tubulin, gamma complex associated protein 4
HGNC id	16691

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MCCRP3 microcephaly with chorioretinopathy 3
Location	15q15.3      Physical location : 43.663.312 - 43.698.238
Synonym name	gamma tubulin ring complex protein (76p gene)
	gamma-tubulin complex component 4
Synonym symbol(s)	GCP4, Hgrip76, 76P, FLJ14797

DNA

TYPE	functioning gene
STRUCTURE	34.95 kb     18 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014444 18 - 3087 NP_055259 - 666 - 1999 10562286

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     moderately Endocrine neuroendocrine pituitary     highly Lymphoid/Immune thymus       moderately Nervous nerve       predominantly Reproductive male system testis     moderately Respiratory respiratory tract larynx     moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal domain binds directly to gamma-tubulin

mono polymer

complex

HOMOLOGY

Homologene

FAMILY

GCP family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text	spindle pole

basic FUNCTION	being necessary for microtubule nucleation at the centrosome
	acting as a structural constituent of cytoskeleton
	its crystal structure provides insight into microtubule nucleation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

gamma-tubulin ring complex composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MCCRP3

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS