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FLASH GENE
Symbol TUBGCP4 contributors: mct - updated : 24-09-2012
HGNC name tubulin, gamma complex associated protein 4
HGNC id 16691
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domain binds directly to gamma-tubulin
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • GCP family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • spindle pole
  • basic FUNCTION
  • being necessary for microtubule nucleation at the centrosome
  • acting as a structural constituent of cytoskeleton
  • its crystal structure provides insight into microtubule nucleation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • gamma-tubulin ring complex composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCRP3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS