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FLASH GENE
Symbol TSR2 contributors: mct - updated : 02-01-2023
HGNC name TSR2 ribosome maturation factor
HGNC id 25455
Corresponding disease
DBA14 Diamond-Blackfan anemia 14 with mandibulofacial dysostosis
Location Xp11.22      Physical location : 54.466.852 - 54.471.728
Synonym name
  • TSR2, 20S rRNA accumulation, homolog
  • WGG motif containing 1
  • escortin
  • Synonym symbol(s) WGG1, DBA14, DT1P1A10, MGC20451
    DNA
    TYPE functioning gene
    STRUCTURE 7.63 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4187 - 96 - 2018 30201955
    5 - 4178 - 96 - 2018 30201955
    5 - 4076 - 191 - 2018 30201955
    5 - 4067 - 188 - 2018 30201955
    4 - 3985 - 96 - 2018 30201955
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a WGG motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • TSR2 is likely involved in the NF-kappaB signaling pathway and may regulate apoptosis
  • TSR2 promotes RPS26 dissociation and stores the released protein for reincorporation
  • importance of TSR2 in adjusting the proper ratio of RPS26-containing and deficient ribosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSR2 releases RPS26 in the presence of high Na+ or pH in vitro and is required for RPS26 release in vivo
  • TSR2 is a chaperone for RPS26, which stabilizes the protein outside of the ribosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA14
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in laryngeal squamous cell carcinoma (LSCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    TSR2-induced apoptosis was mediated by inhibiting the NFKB1 signaling pathway, which may provide an effective target in gene therapy for LSCC
    ANIMAL & CELL MODELS