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FLASH GENE

Symbol

TSPAN32

contributors: npt - updated : 18-11-2003

HGNC name	tetraspanin 32
HGNC id	13410

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.5      Physical location : 2.323.242 - 2.339.430
Synonym name	tumor suppressing subtransferable candidate 6
	pan-hematopoietic expression
	protein Phemx
	tumor-suppressing subchromosomal transferable fragment cDNA 6
Synonym symbol(s)	TSSC6, PHEMX, MGC22455, PHMX

DNA

TYPE	functioning gene
STRUCTURE	16.00 kb     10 Exon(s)

text structure

1 to 8a and 8b

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - NAP1L4 - PHLDA2 - SLC22A18 - CDKN1C - KCNQ1 - TSSC4 - CD81 - TSPAN32 - ASCL2 - TH - INS - IGF2 - H19 - cen
Authors	Nicholson (00)

RNA

TRANSCRIPTS	type	messenger

text	four different spliced transcripts form 1.5 to 4.4 kb

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PHEMX I1 - - 1327 - 320 - Robb PHEMX I 2 - - 1256 - 290 - Robb PHEMX I3 - - 1207 - 124 - Robb PHEMX I 4 - - 1271 - 258 - Robb

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune B cell

cell lineage	hematopoietic cell lineage
cell lines
fluid/secretion

at STAGE

physiological period

fetal

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four hydrophobic regions
	an N terminal cytoplasmic domain
	a transmembrane domain
	a several potential phosphorylations sites

HOMOLOGY

interspecies

ortholog to murine Phemx

intraspecies

homolog to CD81

Homologene

FAMILY

tetraspanin (TM4SF) family

CATEGORY

tumor suppressor , signaling

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

may be playing a role in malignancies and disease that involve this region as well as hematopoietic cell function

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	hematopoiesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS