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FLASH GENE
Symbol TSPAN32 contributors: npt - updated : 18-11-2003
HGNC name tetraspanin 32
HGNC id 13410
Location 11p15.5      Physical location : 2.323.242 - 2.339.430
Synonym name
  • tumor suppressing subtransferable candidate 6
  • pan-hematopoietic expression
  • protein Phemx
  • tumor-suppressing subchromosomal transferable fragment cDNA 6
  • Synonym symbol(s) TSSC6, PHEMX, MGC22455, PHMX
    DNA
    TYPE functioning gene
    STRUCTURE 16.00 kb     10 Exon(s)
    text structure 1 to 8a and 8b
    MAPPING cloned Y linked N status provisional
    Map pter - NAP1L4 - PHLDA2 - SLC22A18 - CDKN1C - KCNQ1 - TSSC4 - CD81 - TSPAN32 - ASCL2 - TH - INS - IGF2 - H19 - cen
    Authors Nicholson (00)
    RNA
    TRANSCRIPTS type messenger
    text four different spliced transcripts form 1.5 to 4.4 kb
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1327 - 320 - Robb
    - - 1256 - 290 - Robb
    - - 1207 - 124 - Robb
    - - 1271 - 258 - Robb
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/ImmuneB cell
    cell lineage hematopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four hydrophobic regions
  • an N terminal cytoplasmic domain
  • a transmembrane domain
  • a several potential phosphorylations sites
  • HOMOLOGY
    interspecies ortholog to murine Phemx
    intraspecies homolog to CD81
    Homologene
    FAMILY
  • tetraspanin (TM4SF) family
  • CATEGORY tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be playing a role in malignancies and disease that involve this region as well as hematopoietic cell function
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS