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FLASH GENE
Symbol TSEN54 contributors: mct/npt - updated : 02-03-2012
HGNC name tRNA splicing endonuclease 54 homolog (S. cerevisiae)
HGNC id 27561
Corresponding disease
PCH2A pontocerebellar hypoplasia 2A
PCH4 pontocerebellar hypoplasia 4
Location 17q25.1      Physical location : 73.512.608 - 73.520.820
Synonym name
  • tRNA splicing endonuclease 54
  • tRNA-intron endonuclease Sen54
    • Synonym symbol(s) LOC283989, HSEN54, sen54, SEN54L, FLJ37147
    DNA
    TYPE functioning gene
    STRUCTURE 8.21 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1970 - 526 - 2004 15109492
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • highly expressed in neurons of the pons, cerebellar dentate and olivary nuclei during the second trimester of pregnancy
  • expressed ubiquitously in the brain, yet strong expression is seen within the telencephalon and metencephalon
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Tsen54
    Homologene
    FAMILY
  • SEN54 family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • requiring for cell growth and division, catalyzing the removal of introns, the first step in tRNA splicing
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a tRNA splicing endonuclease complex consisting of four subunits : TSEN2, TSEN15, TSEN34 and TSEN54
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH2A , PCH4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS