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Symbol TSEN54 contributors: mct/npt - updated : 02-03-2012
HGNC name tRNA splicing endonuclease 54 homolog (S. cerevisiae)
HGNC id 27561
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Tsen54
Homologene
FAMILY
  • SEN54 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • requiring for cell growth and division, catalyzing the removal of introns, the first step in tRNA splicing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a tRNA splicing endonuclease complex consisting of four subunits : TSEN2, TSEN15, TSEN34 and TSEN54
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH2A , PCH4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS