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FLASH GENE
Symbol TRPM7 contributors: shn/pgu - updated : 28-08-2013
HGNC name transient receptor potential cation channel, subfamily M, member 7
HGNC id 17994
Corresponding disease
ALSPD amyotophic lateral sclerosis-parkinsonism/dementia complex of Guam
Location 15q21.2      Physical location : 50.849.353 - 50.979.012
Synonym name
  • LTRPC ion channel family member 7
  • transient receptor potential melastatin 7
  • Synonym symbol(s) CHAK, LTRPC7, CHAK1, TRP-PLIK, FLJ20117, FLJ25718
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 126.50 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D15S126 - D15S119 - TRPM7 - D15S1017 - D15S220 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    39 - 7255 213 1865 - 2008 18539771
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartconducting system  highly Homo sapiensFetal
    Digestiveesophagus   highly
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Nervousbrain   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiacmyocardiumhighly Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane domains
  • one coiled-coil regions
  • one MHCK/EEF2-alpha-kinase homology domain, that may play a structural role in channel assembly or subcellular localization
  • a TRP (EWK/FHR) channel domain and a zinc finger containing an alpha-kinase domain fused to an ion channel (a fused alpha kinase domain)
  • C terminus enzymatically active and structurally homologous to other protein kinases except for the inclusion of a zinc-finger domain, and 14 phosphorylation sites located on the cytoplasmic C terminus
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Trpm7, Mus musculus
    ortholog to TRPM7, Pan troglodytes
    ortholog to trpm7, Danio rerio
    ortholog to Trpm7, Rattus norvegicus
    intraspecies homolog to MLSN1
    homolog to TRPM6
    Homologene
    FAMILY
  • MHCK/EF2 kinase domain family
  • TRP superfamily of CA2+ cation channels subfamily
  • CATEGORY enzyme , receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localized in the membrane of sympathetic neuronal acetylcholine (ACh)-secreting synaptic vesicles as part of a molecular complex of synaptic vesicle-specific proteins
    basic FUNCTION
  • a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death
  • having protein kinase activity modulated by Mg(2+)
  • cation channel fused to an alpha-kinase, regulating the cell adhesion that is the combined effect of kinase-dependent and -independent pathways on actomyosin contractility
  • being both an ion channel and a kinase, that forms a molecular complex with proteins of the vesicular fusion machinery, and is critical for stimulated neurotransmitter release
  • facilitates cholinergic vesicle fusion with the plasma membrane
  • implicated in the uptake of Mg2+ into vertebrate cells
  • acting as a kinase
  • essential for embryonic development
  • positioned alongside phosphoinositide 3-kinases as a central regulator of lymphocyte growth and proliferation
  • may govern cell death pathways
  • excessive TRPM7 channel activity causes oxidative and nitrosative stresses, producing cell rounding mediated by MAPK14/JNK-dependent activation of m-calpain
  • essential role for the ion channel TRPM7 and Mg(2+) in RAC1-dependent polarized cell movements during vertebrate gastrulation
  • a Ca²+- and Mg²+-permeant ion channel in possession of its own kinase domain
  • unique fusion of a Mg(2+) permeable pore with an active cytosolic kinase domain, and is considered a master regulator of cellular Mg(2+) homeostasis
  • magnesium and TRPM7 are modulators of the angiogenic phenotype of microvascular endothelial cells
  • essential for kidney development from metanephric mesenchyme but not ureteric bud
  • temporal and spatial requirement of TRPM7 for embryogenesis and organogenesis
  • divalent cation-selective ion channels that are permeable to Ca2+ and Mg2+
  • functional TRPM7 channels are present in atrial myocytes, and the channel expression is upregulated in the atria with atrial fibrillation
  • cation channel identified as a ubiquitous magnesium transporter
  • modulates endothelial behavior and any condition leading to TRPM7 upregulation might impair endothelial function
  • plays a critical role in breast cancer cell migration through its kinase domain
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS development , active transport
    text
  • ion channel
  • Mg2+ homeostasis
  • being essential for embryonic development
  • PATHWAY
    metabolism
    signaling
    a component
  • complexing with TRPM6 for the biological role of TRPM6 in epithelial magnesium absorption
  • INTERACTION
    DNA
    RNA
    small molecule
    Mg(2+) and Mn(2+)
    protein
  • phosphorylates annexin 1, ANX1
  • transient receptor potential cation channel, subfamily M, member 6, TRMP6
  • functions synergistically with non-canonical Wnt signaling to regulate RAC1 activity
  • annexin A1 (ANXA1) is a substrate for TRPM7 kinase and TRPM7 phosphorylates annexin A1 at Ser5 within the N-terminal alpha-helix
  • influences diastolic membrane depolarization and automaticity in sinoatrial node (SAN) indirectly via regulation of HCN4 expression
  • is a MLKL downstream target for the mediation of Ca2+ influx and TNF-induced necroptosis
  • cell & other
    REGULATION
    Other regulated by levels of intracellular MgATP,MgGTP
    inactivated by phosphatidylinositol 4,5-bisphosphate (PIP(2))
    ASSOCIATED DISORDERS
    corresponding disease(s) ALSPD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • novel biomarker in the treatment of oestrogen receptor negative (ER-) invasive ductal carcinoma (
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential therapeutic target in the treatment of oestrogen receptor negative (ER-) invasive ductal carcinoma
    ANIMAL & CELL MODELS
  • Trpm7 deletion in mice is lethal before day 7.5 of embryogenesis
  • TRPM7 suppression in hippocampal CA1 of adult rats neurons made them resistant to ischemic death after brain ischemia and preserved neuronal morphology and function