basic FUNCTION
| a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death |
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having protein kinase activity modulated by Mg(2+) |
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cation channel fused to an alpha-kinase, regulating the cell adhesion that is the combined effect of kinase-dependent and -independent pathways on actomyosin contractility |
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being both an ion channel and a kinase, that forms a molecular complex with proteins of the vesicular fusion machinery, and is critical for stimulated neurotransmitter release |
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facilitates cholinergic vesicle fusion with the plasma membrane |
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implicated in the uptake of Mg2+ into vertebrate cells |
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acting as a kinase |
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essential for embryonic development |
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positioned alongside phosphoinositide 3-kinases as a central regulator of lymphocyte growth and proliferation |
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may govern cell death pathways |
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excessive TRPM7 channel activity causes oxidative and nitrosative stresses, producing cell rounding mediated by MAPK14/JNK-dependent activation of m-calpain |
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essential role for the ion channel TRPM7 and Mg(2+) in RAC1-dependent polarized cell movements during vertebrate gastrulation |
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a Ca²+- and Mg²+-permeant ion channel in possession of its own kinase domain |
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unique fusion of a Mg(2+) permeable pore with an active cytosolic kinase domain, and is considered a master regulator of cellular Mg(2+) homeostasis |
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magnesium and TRPM7 are modulators of the angiogenic phenotype of microvascular endothelial cells |
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essential for kidney development from metanephric mesenchyme but not ureteric bud |
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temporal and spatial requirement of TRPM7 for embryogenesis and organogenesis |
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divalent cation-selective ion channels that are permeable to Ca2+ and Mg2+ |
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functional TRPM7 channels are present in atrial myocytes, and the channel expression is upregulated in the atria with atrial fibrillation |
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cation channel identified as a ubiquitous magnesium transporter |
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modulates endothelial behavior and any condition leading to TRPM7 upregulation might impair endothelial function |
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plays a critical role in breast cancer cell migration through its kinase domain |
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with TRPM6, are unique proteins as they combine an ion channel domain with a C-terminally fused protein kinase domain |