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Symbol TRPC4AP contributors: mct - updated : 04-03-2011
HGNC name transient receptor potential cation channel, subfamily C, member 4 associated protein
HGNC id 16181
Location 20q11.23      Physical location : 33.590.214 - 33.680.618
Synonym name
  • TRP4-associated protein
  • chromosome 20 open reading frame 188
  • short transient receptor potential channel 4 associated protein
  • tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein
  • Synonym symbol(s) TRUSS, TRRP4AP, C20orf188
    TYPE functioning gene
    STRUCTURE 90.41 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    ASIP 20q11.21 agouti signaling protein, nonagouti homolog (mouse) AHCY 20cen-q13.1 S-adenosylhomocysteine hydrolase ITCH 20q11.22-23 itchy homolog E3 ubiquitin protein ligase (mouse) CDC42P1 20q11.22 cell division cycle 42 pseudogene 1 FDXP1 20cen-q13.1 ferredoxin pseudogene 1 FLJ38773 20q11.22 hypothetical protein FLJ38773 DNCL2A 20q12-q13.1 dynein, cytoplasmic, light polypeptide 2A MAP1LC3A 20cen-q13 microtubule-associated protein 1 light chain 3 alpha CDC91L1 20q11.21 CDC91 cell division cycle 91-like 1 (S. cerevisiae) NCOA6 20q11 nuclear receptor coactivator 6 HMG4L 20q11.21 high-mobility group (nonhistone chromosomal) protein 4-like GGTL3 20pter-p13 gamma-glutamyltransferase-like 3 ACAS2 20q11.2-q12 acetyl-Coenzyme A synthetase 2 (ADP forming) GSS 20q11.21 glutathione synthetase MYH7B 20q11.21 myosin, heavy polypeptide 7B, cardiac muscle, beta TRPC4AP 20q11.23 transient receptor potential cation channel, subfamily C, member 4 associated protein C20orf31 20q11.23 chromosome 20 open reading frame 31 PROCR 20q11.21 protein C receptor, endothelial (EPCR) MMP24 20q11.2 matrix metalloproteinase 24 (membrane-inserted) ITGB4BP 20q11.2 integrin beta 4 binding protein C20orf128 20q11.21 chromosome 20 open reading frame 128 C20orf44 20q11.23 chromosome 20 open reading frame 44 GDF5 20q11.2 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) CEP2 20pter-q12 centrosomal protein 2 LOC343705 20q11.23 similar to beta-galactoside alpha-2,3-sialyltransferase C20orf173 20q11.22 chromosome 20 open reading frame 173 SDBCAG84 20pter-q12 serologically defined breast cancer antigen 84 FER1L4 20q11.21 fer-1-like 4 (C. elegans) RPL37P1 11q13 ribosomal protein L37 pseudogene 1 LOC375095 20q11.23 similar to dJ309K20.1.1 (novel protein similar to dysferlin, isoform 1) SPAG4 20q11.2 sperm associated antigen 4 CPNE1 20q11.21 copine I RBM12 20q11.21 RNA binding motif protein 12 NFS1 20q11-q12 NFS1 nitrogen fixation 1 (S. cerevisiae) C20orf52 20q11.23 chromosome 20 open reading frame 52 RNPC2 20q11.21 RNA-binding region (RNP1, RRM) containing 2
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3189 90.85 797 - 2010 20704259
  • containing exon 9a (longer than 9b)
  • 19 splicing 3165 89.91 789 - 2010 20704259
  • containing exon 9b (shorter than 9a)
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon moderately
     liver   lowly
    Lymphoid/Immunespleen   lowly
     thymus   highly
    Reproductivefemale systemuteruscervix moderately
     male systemprostate  moderately
     male systemtestis  moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines promonocytic cell line
    at STAGE
    PHYSICAL PROPERTIES globular Hydrophobic
  • the entire N-terminal region (AAs 1-440) is involved in its interaction with TNFRSF1A and within this region, AAs 249-440 play an important role, and also also important for the interaction with TRAF2
  • putative ser/thr and tyr kinase phosphorylation sites
  • two putative TRAF2 binding sites
  • C-terminal region may contribute to its oligomerization
  • mono polymer monomer , trimer
    interspecies homolog to rattus Trpc4ap (97.74 pc)
    homolog to murine Trpc4ap (97.47 pc)
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • transporter activity
  • may be participating in the activation of NFKB1 in response to TNFRSF1A ligation
  • could serve as a scaffolding protein to link to TNFRSF1A to the IKK signaling complex
  • suppresses Myc-mediated transactivation and transformation in a dose-dependent manner
  • may contribute to the regulation of TNFRSF1A signaling, possibly by facilitating the assembly and/or dissociation of TNFRSF1A signaling complexes
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    signaling signal transduction
    a component may exist both as a monomeric species (90 kDa) and as homomeric complexes, including a trimer (270 kDa)
    small molecule nucleotide,
    ATP binding
  • constitutively associated with TNFRSF1A
  • interacts with TRADD, TRAF2, CHUK, IKBKB, IKBKG
  • TAP1, TAP2 binding
  • activating AP1 & JNK
  • receptor for a DDB1 (damage-specific DNA-binding protein 1)-CUL4 (Cullin 4) E3 ligase complex for selective Myc degradation through the proteasome
  • binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus
  • interacted with only TNFRSF1A, TRAF2, and IKBKG
  • interacts with TNFRSF1A through an N-Terminal region containing AAs 249-440
  • binds to TRAF2 in a manner independent of these putative TRAF2 binding motifs
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in most cancer cell lines, leading to Myc protein stabilization
    Susceptibility to Alzheimer disease
    Variant & Polymorphism other haplotype identified in two extended pedigrees with late-onset Alzheimer disease
    Candidate gene
    Therapy target