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FLASH GENE
Symbol TRPC4AP contributors: mct - updated : 04-03-2011
HGNC name transient receptor potential cation channel, subfamily C, member 4 associated protein
HGNC id 16181
Location 20q11.23      Physical location : 33.590.214 - 33.680.618
Synonym name
  • TRP4-associated protein
  • chromosome 20 open reading frame 188
  • short transient receptor potential channel 4 associated protein
  • tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein
  • Synonym symbol(s) TRUSS, TRRP4AP, C20orf188
    DNA
    TYPE functioning gene
    STRUCTURE 90.41 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    ASIP 20q11.21 agouti signaling protein, nonagouti homolog (mouse) AHCY 20cen-q13.1 S-adenosylhomocysteine hydrolase ITCH 20q11.22-23 itchy homolog E3 ubiquitin protein ligase (mouse) CDC42P1 20q11.22 cell division cycle 42 pseudogene 1 FDXP1 20cen-q13.1 ferredoxin pseudogene 1 FLJ38773 20q11.22 hypothetical protein FLJ38773 DNCL2A 20q12-q13.1 dynein, cytoplasmic, light polypeptide 2A MAP1LC3A 20cen-q13 microtubule-associated protein 1 light chain 3 alpha CDC91L1 20q11.21 CDC91 cell division cycle 91-like 1 (S. cerevisiae) NCOA6 20q11 nuclear receptor coactivator 6 HMG4L 20q11.21 high-mobility group (nonhistone chromosomal) protein 4-like GGTL3 20pter-p13 gamma-glutamyltransferase-like 3 ACAS2 20q11.2-q12 acetyl-Coenzyme A synthetase 2 (ADP forming) GSS 20q11.21 glutathione synthetase MYH7B 20q11.21 myosin, heavy polypeptide 7B, cardiac muscle, beta TRPC4AP 20q11.23 transient receptor potential cation channel, subfamily C, member 4 associated protein C20orf31 20q11.23 chromosome 20 open reading frame 31 PROCR 20q11.21 protein C receptor, endothelial (EPCR) MMP24 20q11.2 matrix metalloproteinase 24 (membrane-inserted) ITGB4BP 20q11.2 integrin beta 4 binding protein C20orf128 20q11.21 chromosome 20 open reading frame 128 C20orf44 20q11.23 chromosome 20 open reading frame 44 GDF5 20q11.2 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) CEP2 20pter-q12 centrosomal protein 2 LOC343705 20q11.23 similar to beta-galactoside alpha-2,3-sialyltransferase C20orf173 20q11.22 chromosome 20 open reading frame 173 SDBCAG84 20pter-q12 serologically defined breast cancer antigen 84 FER1L4 20q11.21 fer-1-like 4 (C. elegans) RPL37P1 11q13 ribosomal protein L37 pseudogene 1 LOC375095 20q11.23 similar to dJ309K20.1.1 (novel protein similar to dysferlin, isoform 1) SPAG4 20q11.2 sperm associated antigen 4 CPNE1 20q11.21 copine I RBM12 20q11.21 RNA binding motif protein 12 NFS1 20q11-q12 NFS1 nitrogen fixation 1 (S. cerevisiae) C20orf52 20q11.23 chromosome 20 open reading frame 52 RNPC2 20q11.21 RNA-binding region (RNP1, RRM) containing 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3189 90.85 797 - 2010 20704259
  • containing exon 9a (longer than 9b)
  • 19 splicing 3165 89.91 789 - 2010 20704259
  • containing exon 9b (shorter than 9a)
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon moderately
     liver   lowly
    Lymphoid/Immunespleen   lowly
     thymus   highly
    Reproductivefemale systemuteruscervix moderately
     male systemprostate  moderately
     male systemtestis  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines promonocytic cell line
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular Hydrophobic
    STRUCTURE
    motifs/domains
  • the entire N-terminal region (AAs 1-440) is involved in its interaction with TNFRSF1A and within this region, AAs 249-440 play an important role, and also also important for the interaction with TRAF2
  • putative ser/thr and tyr kinase phosphorylation sites
  • two putative TRAF2 binding sites
  • C-terminal region may contribute to its oligomerization
  • mono polymer monomer , trimer
    HOMOLOGY
    interspecies homolog to rattus Trpc4ap (97.74 pc)
    homolog to murine Trpc4ap (97.47 pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • transporter activity
  • may be participating in the activation of NFKB1 in response to TNFRSF1A ligation
  • could serve as a scaffolding protein to link to TNFRSF1A to the IKK signaling complex
  • suppresses Myc-mediated transactivation and transformation in a dose-dependent manner
  • may contribute to the regulation of TNFRSF1A signaling, possibly by facilitating the assembly and/or dissociation of TNFRSF1A signaling complexes
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component may exist both as a monomeric species (90 kDa) and as homomeric complexes, including a trimer (270 kDa)
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • constitutively associated with TNFRSF1A
  • interacts with TRADD, TRAF2, CHUK, IKBKB, IKBKG
  • TAP1, TAP2 binding
  • activating AP1 & JNK
  • receptor for a DDB1 (damage-specific DNA-binding protein 1)-CUL4 (Cullin 4) E3 ligase complex for selective Myc degradation through the proteasome
  • binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus
  • interacted with only TNFRSF1A, TRAF2, and IKBKG
  • interacts with TNFRSF1A through an N-Terminal region containing AAs 249-440
  • binds to TRAF2 in a manner independent of these putative TRAF2 binding motifs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in most cancer cell lines, leading to Myc protein stabilization
    Susceptibility to Alzheimer disease
    Variant & Polymorphism other haplotype identified in two extended pedigrees with late-onset Alzheimer disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS