Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TRPC4AP | contributors: mct - updated : 04-03-2011 |
HGNC name | transient receptor potential cation channel, subfamily C, member 4 associated protein |
HGNC id | 16181 |
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Location | 20q11.23 Physical location : 33.590.214 - 33.680.618 |
Synonym name | |
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Synonym symbol(s) | TRUSS, TRRP4AP, C20orf188 |
DNA |
TYPE | functioning gene |
STRUCTURE | 90.41 kb 19 Exon(s) |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| promonocytic cell line | fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES | globular | Hydrophobic | ||
STRUCTURE |
motifs/domains
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mono polymer | monomer , trimer |
HOMOLOGY |
interspecies | homolog to rattus Trpc4ap (97.74 pc) |
homolog to murine Trpc4ap (97.47 pc) |
Homologene |
FAMILY |
CATEGORY | signaling |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,lumen | |
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth |
basic FUNCTION | |
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CELLULAR PROCESS | cell life, cell death/apoptosis |
PHYSIOLOGICAL PROCESS | cellular trafficking transport |
PATHWAY |
metabolism |
signaling | signal transduction |
a component | may exist both as a monomeric species (90 kDa) and as homomeric complexes, including a trimer (270 kDa) |
INTERACTION |
DNA |
RNA |
small molecule | nucleotide, |
ATP binding |
protein | |
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cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility | to Alzheimer disease |
Variant & Polymorphism other | haplotype identified in two extended pedigrees with late-onset Alzheimer disease |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |