basic FUNCTION
| playing a role in signal transduction and growth control |
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playing a role in the maintenance of the normal phenotype |
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having cation channel activity |
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candidate for the mechanosensitive transduction channel of cochlear ear cells, participating in the perception of sounds |
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is an important component of the transduction machinery through which environmental irritants and endogenous proalgesic agents depolarize nociceptors to elicit inflammatory pain |
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acting as a ionotropic cannabinoid receptor |
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implicated in the mediation of nociceptive and inflammatory signals in response to pungent ingredients, in the development of cold hyperalgesia following inflammation and nerve injury as well as a role in mechanosensation |
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acts as a major sensor for noxious cold |
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acts as a sensor molecule for enterochromaffin cells and may regulate gastrointestinal function |
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is an essential component of the signaling pathways that promote histamine-independent itch |
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TRPV1 and TRPA1, are necessary for development of inflammatory hypersensitivity and are functionally potentiated by growth factors |
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TRPV1 and TRPA1 induced MUC5B release in the nasal airways |
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activation mechanism of TRPA1 may involve N-terminal conformation changes and disulfide bonding between critical cysteine residues |
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activation of meningeal TRPA1 via endogenous or exogenous mechanisms can lead to afferent signaling and headache |
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regulates both itch transduction and pathophysiological changes in the skin that promote chronic itch |
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TRPV1 and TRPA1 in vestibular ganglion (VG) neurons might participate in vestibular function and/or dysfunction such as vertigo |
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function of TRPA1 in cellular function associated to the regulation of agonist-induced Ca(2+) entry by the modulation of STIM1/ORAI1 interaction |
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TRPA1, like TRPV1, mediates F2RL1-triggered pancreatic nociception and that TRPA1 in collaboration with TRPV1 latently contributes to pancreatitis-related pain |
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is essential to the nociceptive effects induced by one of the most important mediators of inflammatory pain, prostaglandin E2 (PGE2) |
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TRPV1, TRPA1, and TRPM8 are important to start up a systemic response of energy expenditure, energy allocation, and water retention |
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considered to be a key player in nociception and inflammatory pain |
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chemo-sensitive cation channel that can be activated by a variety of external and internal stimuli, leading to the influx of Ca2+ |
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TRPA1 channels may be determinants of Airway smooth muscle (ASM) contractility and local inflammation control, positioning them as part of novel mechanisms that control (patho)physiological function of airways and ASM |
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BDKRB1 and the transient receptor potential ankyrin 1 (TRPA1) work as initiators and gatekeepers of nociception and inflammation |