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FLASH GENE
Symbol TRPA1 contributors: mct - updated : 27-02-2016
HGNC name transient receptor potential cation channel, subfamily A, member 1
HGNC id 497
ASSOCIATED DISORDERS
corresponding disease(s) FEPS1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in mesenchymal tumor
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
miscelleaneouspain 
represents a promising target for the prevention or treatment of cold-induced pain
miscelleaneouspain 
promising novel drug target for the treatment of chronic pain and hypersensitivity
neurosensorial  
future TRPA1 modulating drugs may modify the perception of odorants
respiratory  
TRPM8 and TRPA1 agonists may be promising new therapies for asthma
ANIMAL & CELL MODELS
  • TRPA1-deficient mice displayed little to no scratching in response to the pruritogens