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FLASH GENE
Symbol TRMT112 contributors: mct/npt - updated : 04-11-2019
HGNC name tRNA methyltransferase 11-2 homolog (S. cerevisiae)
HGNC id 26940
Location 11q13.1      Physical location : 64.084.167 - 64.085.033
Synonym name
  • TRM112-like protein2
  • HSPC170 protein2
    • Synonym symbol(s) HSPC152, HSPC170, TRM112, TRMT11-2, hTrm112
    DNA
    TYPE functioning gene
    STRUCTURE 2.14 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 812 - 125 - 2015 25851604
    5 - 980 - 125 - 2015 25851604
    5 - 957 - 125 - 2015 25851604
    4 - 797 - 120 - 2015 25851604
    4 - 901 - 106 - 2015 25851604
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • TRM112 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    basic FUNCTION
  • small accessory protein, having methyltransferase activity
  • might be involved in the morphogenesis of diverse organs and tissues and numerous physiological functions
  • DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA
  • METTL5 works in close association with TRMT112 and is stabilized by it
  • METTL5 and ZCCHC4 are not essential to growth or ribosome biogenesis, and METTL5 gains metabolic stability by associating with human TRMT112
  • TRMT112 is involved in cellular quality control ensuring that N6AMT1 isoform with missing substrate binding domain is eliminated from the cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • N6AMT1 functions as an obligate heterodimer with TRMT112, writing the methylation mark on lysine 12 of histone H4 (H4K12)
  • last complex formed between TRMT112 and BUD23 proteins modifies 18S rRNA and participates in the 40S biogenesis pathway
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with ALKBH8 (interaction with TRM112, required to form a functional tRNA methyltransferase) (Songe-Møller 2010)
  • TRMT112 is the interaction partner of WBSCR22, and stability of WBSCR22 is regulated through the interaction with TRMT112
  • TRMT112, a small protein (COG2835) conserved in all three domains of life, interacts and activates four methyltransferases (BUD23,N6AMT1) that target different components of the translation machinery (rRNA, tRNAs, release factors)
  • TRMT112 is a general partner for methyltransferases in all living organisms
  • METTL5–TRMT112 acts by extruding the adenosine to be modified from a double-stranded nucleic acid
  • TRMT112 regulates the expression of N6AMT1 isoforms in mammalian cells
  • TRMT112 binds to a hydrophobic surface of N6AMT1 to stabilize its structure but does not directly contribute to substrate binding and catalysis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS