protein
| interaction with ALKBH8 (interaction with TRM112, required to form a functional tRNA methyltransferase) (Songe-Møller 2010) |
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TRMT112 is the interaction partner of WBSCR22, and stability of WBSCR22 is regulated through the interaction with TRMT112 |
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TRMT112, a small protein (COG2835) conserved in all three domains of life, interacts and activates four methyltransferases (BUD23,N6AMT1) that target different components of the translation machinery (rRNA, tRNAs, release factors) |
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TRMT112 is a general partner for methyltransferases in all living organisms |
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METTL5–TRMT112 acts by extruding the adenosine to be modified from a double-stranded nucleic acid |
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TRMT112 regulates the expression of N6AMT1 isoforms in mammalian cells |
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TRMT112 binds to a hydrophobic surface of N6AMT1 to stabilize its structure but does not directly contribute to substrate binding and catalysis |