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FLASH GENE
Symbol TRIP6 contributors: mct - updated : 04-07-2011
HGNC name thyroid hormone receptor interactor 6
HGNC id 12311
Location 7q22.1      Physical location : 100.464.949 - 100.471.070
Synonym name
  • zyxin related protein 1
  • OPA-interacting protein 1
  • Synonym symbol(s) OIP1, ZRP-1, MGC10556, MGC10558, MGC29959
    DNA
    TYPE functioning gene
    STRUCTURE 6.13 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D7S479 - [EPO , TRIP6 , AUTS2 AUTS2 ] - D7S2446 - qter
    Authors Yi (98)
    Physical map
    PILRA 7q22 paired immunoglobin-like type 2 receptor alpha ZCWPW1 7q22.1 zinc finger, CW-type with PWWP domain 1 FLJ20257 7q22.1 hypothetical protein FLJ20257 MGC22793 7q22.1 hypothetical protein MGC22793 THG-1 7p21-p15 TSC-22-like FLJ37538 7q22.1 hypothetical protein FLJ37538 HRBL 7q22 HIV-1 Rev binding protein-like LOC392081 7 similar to insulin receptor substrate like protein LRRN4 7q22 leucine rich repeat neuronal 4 FBXO24 7q22 F-box only protein 24 PCOLCE 7q22 procollagen C-endopeptidase enhancer AF053356_CDS3 7q22 hypothetical protein AF053356_CDS3 TFR2 7q22 transferrin receptor 2 ACTL6 7q22 actin-like 6 GNB2 7q21.1-q22.2 guanine nucleotide binding protein (G protein), beta polypeptide 2 PERQ1 7q22 PERQ amino acid rich, with GYF domain 1 RPP20 7q22 POP7 (processing of precursor, S. cerevisiae) homolog EPO 7q21.3-q22.1 erythropoietin ZAN 7q22 zonadhesin EPHB4 7q32-q36 EphB4 LOC285995 7q22.1 hypothetical LOC285995 SLC12A9 7q22 solute carrier family 12 (potassium/chloride transporters), member 9 TRIP6 7q22 thyroid hormone receptor interactor 6 ARS2 7q21 arsenate resistance protein ARS2 ACHE 7q22.1 acetylcholinesterase (YT blood group) MUC3B 7q22 mucin 3B LOC219612 7q22.1 hypothetical gene supported by AK025404 MUC17 7q22 mucin 17 TRIM56 7q11.2 tripartite motif-containing 56 SERPINE1 7q21.3-q22.1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 AP1S1 7q11.22 adaptor-related protein complex 1, sigma 1 subunit VGF 7q22 VGF nerve growth factor inducible FLJ39237 7q22.1 FLJ39237 protein MGAT3 22q13.1 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase PLOD3 7q36 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 ZNHIT1 7q22.1 zinc finger, HIT domain containing 1 CLDN15 7q22 claudin 15 TTC11 7q22.1 tetratricopeptide repeat domain 11
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1762 - 476 - 1998 9598321
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   moderately
    Lymphoid/Immunethymus   moderately
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuteruscervix predominantly
     female systemovary  highly
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Urinarykidney   moderately
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal proline rich region
  • three C-terminal cysteine-rich LIM/double zinc finger motifs, through the LIM domain-mediated protein-protein interactions, TRIP6 forms complexes with several molecules involved in actin rearrangement, cell adhesion, and migration
  • a nuclear receptor interaction motif (LXXLL)
  • C-terminal LIM3 and PDZ-binding domain have been demonstrated to mediate the interaction with the second PDZ domain of PTPL1
  • HOMOLOGY
    intraspecies homolog to LPP and ZYX (see symbols)
    Homologene
    FAMILY LIM containing proteins family, zyxin family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,chromatin/chromosome,telomere
    text
  • TRIP6 and LPP, detected at a small subset of telomeres, perhaps those that are critically short
  • basic FUNCTION
  • functioning at a point of convergence between the activated EDG2 and downstream signals involved in cell adhesion and migration
  • implicated in cell motility and transcriptional control
  • focal adhesion molecule with the capability to shuttle between cell surface and nucleus
  • nuclear isoform of TRIP6, acts as a co-activator for AP-1 and NF-kappaB transcription factors
  • erves as the molecular mediator of the crosstalk between nuclear receptors and other transcription factors in that it assembles these factors at promoters
  • critical downstream regulator of SRC signaling and its phosphorylation is permissive for its presence in the sealing zone where it plays a positive role in osteoclast bone resorptive capacity
  • regulates nuclear translocation and the activation of NFKB upon FAS activation or LPA stimulation, and antagonizes FAS-induced apoptosis and further enhances the antiapoptotic effect of LPA in cells that express high levels of TRIP6
  • specific LIM proteins (TRIP6 and LPP) are part of complex events occurring in the context of the telomere dysfunction response, and possibly at play during the induction of senescence
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component PTPN13, PDLIM4 and TRIP6 may function as components of multi-protein complexes at actin-based sub-cellular structures
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • thyroid hormone receptor
  • interacting with endoglin for regulation of the actin cytoskeletal organization
  • interacting with the second out of five PDZ motifs in PTP-BL
  • interacting with TRIP6 (TRIP6 directly binds to the third PDZ domain of SCRIB via its carboxy-terminus)
  • interacted directly with MAGI1 by binding to its fifth PDZ domain
  • interaction with NF-kappaB and AP-1 at a glucocorticoid receptor -bound promoter is required for the repression
  • binds to the cytoplasmic juxtamembrane domain of FAS and interferes with the recruitment of FADD to FAS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS