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FLASH GENE
Symbol TRIP6 contributors: mct - updated : 04-07-2012
HGNC name thyroid hormone receptor interactor 6
HGNC id 12311
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Lymphoid/Immunethymus   moderately
Nervousnervecranial nerve  highly
Reproductivefemale systemuteruscervix predominantly
 female systemovary  highly
Respiratorylung   moderately
Skin/Tegumentskin   highly
Urinarykidney   moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal proline rich region
  • three C-terminal cysteine-rich LIM/double zinc finger motifs, through the LIM domain-mediated protein-protein interactions, TRIP6 forms complexes with several molecules involved in actin rearrangement, cell adhesion, and migration
  • a nuclear receptor interaction motif (LXXLL)
  • C-terminal LIM3 and PDZ-binding domain have been demonstrated to mediate the interaction with the second PDZ domain of PTPL1
  • HOMOLOGY
    intraspecies homolog to LPP and ZYX (see symbols)
    Homologene
    FAMILY LIM containing proteins family, zyxin family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,chromatin/chromosome,telomere
    text
  • TRIP6 and LPP, detected at a small subset of telomeres, perhaps those that are critically short
  • basic FUNCTION
  • functioning at a point of convergence between the activated EDG2 and downstream signals involved in cell adhesion and migration
  • implicated in cell motility and transcriptional control
  • focal adhesion molecule with the capability to shuttle between cell surface and nucleus
  • nuclear isoform of TRIP6, acts as a co-activator for AP-1 and NF-kappaB transcription factors
  • erves as the molecular mediator of the crosstalk between nuclear receptors and other transcription factors in that it assembles these factors at promoters
  • critical downstream regulator of SRC signaling and its phosphorylation is permissive for its presence in the sealing zone where it plays a positive role in osteoclast bone resorptive capacity
  • regulates nuclear translocation and the activation of NFKB upon FAS activation or LPA stimulation, and antagonizes FAS-induced apoptosis and further enhances the antiapoptotic effect of LPA in cells that express high levels of TRIP6
  • specific LIM proteins (TRIP6 and LPP) are part of complex events occurring in the context of the telomere dysfunction response, and possibly at play during the induction of senescence
  • multifunctional protein involved in various physiological and pathological processes, including cell migration and tumorigenesis (POMID: 25673849)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component PTPN13, PDLIM4 and TRIP6 may function as components of multi-protein complexes at actin-based sub-cellular structures
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • thyroid hormone receptor
  • interacting with endoglin for regulation of the actin cytoskeletal organization
  • interacting with the second out of five PDZ motifs in PTP-BL
  • interacting with TRIP6 (TRIP6 directly binds to the third PDZ domain of SCRIB via its carboxy-terminus)
  • interacted directly with MAGI1 by binding to its fifth PDZ domain
  • interaction with NF-kappaB and AP-1 at a glucocorticoid receptor -bound promoter is required for the repression
  • binds to the cytoplasmic juxtamembrane domain of FAS and interferes with the recruitment of FADD to FAS
  • TRIP6-GRIP1-MYO6 interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS