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FLASH GENE
Symbol TRIM59 contributors: mct - updated : 08-12-2015
HGNC name tripartite motif-containing 59
HGNC id 30834
Location 3q25.33      Physical location : 160.153.291 - 160.167.626
Synonym name
  • tumor suppressor TSBF1
  • RING finger 1-like
  • tripartite motif-containing 57
  • RING finger protein 104
  • IFT80 long isoform
    • Synonym symbol(s) MRF1, TSBF1, TRIM57, RNF104, MGC129860, MGC129861, MGC26631, IFT80L
    DNA
    TYPE functioning gene
    STRUCTURE 14.34 kb     3 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D3S3575 - D3S3580 - TRIM59 - D3S3579 - D3S3708 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3886 47 403 - 2002 12095697
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vesselaorta  highly
    Digestiveliver   highly
     stomach    
    Lymphoid/Immunelymph node    
    Nervousbrain   highly
    Reproductivefemale systemuterus   
     male systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain
  • a type 2 B-box domain
  • a coiled-coil domain
  • a transmembrane domain
    • HOMOLOGY
    interspecies homolog to murine Trim59 (82.8 pc)
    Homologene
    FAMILY
  • C-XI TRIM family
  • TRIM/RBCC family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • acting as an ESR1-interacting corepressor protein (Georgescu 2005)
  • like other IFT proteins, plays an important role in cell proliferation and differentiation
  • TRIM59 may serve as a multifunctional regulator for innate immune signaling pathways
  • might be an essential accessory molecule in mediating BCG-activated macrophages (BAM) tumoricidal functions and is a phagocytosis-correlated molecule
  • may promote Non-Small Cell Lung Cancer cell growth through other pathways but not the TP53 signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • binding to both the N terminus and the C terminus of ESR1 (Georgescu 2005)
  • interacting in a ligand-dependent manner with thyroid receptor alpha, retinoid X receptor alpha, and androgen receptor (Georgescu 2005)
  • interacting in a ligand-independent manner with ESR2 and the retinoic acid receptor (Georgescu 2005)
  • TRIM59, interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway
  • TRIM59 interacts with TP53, promoting its ubiquitination and degradation, and might promote gastric carcinogenesis via this mechanism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human gastric tumors compared with nontumor tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS