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FLASH GENE

Symbol

TRIM59

contributors: mct - updated : 08-12-2015

HGNC name	tripartite motif-containing 59
HGNC id	30834

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessel aorta     highly Digestive liver       highly   stomach         Lymphoid/Immune lymph node         Nervous brain       highly Reproductive female system uterus         male system testis       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RING finger domain
	a type 2 B-box domain
	a coiled-coil domain
	a transmembrane domain

HOMOLOGY

interspecies

homolog to murine Trim59 (82.8 pc)

Homologene

FAMILY	C-XI TRIM family
	TRIM/RBCC family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus

basic FUNCTION	acting as an ESR1-interacting corepressor protein (Georgescu 2005)
	like other IFT proteins, plays an important role in cell proliferation and differentiation
	TRIM59 may serve as a multifunctional regulator for innate immune signaling pathways
	might be an essential accessory molecule in mediating BCG-activated macrophages (BAM) tumoricidal functions and is a phagocytosis-correlated molecule
	may promote Non-Small Cell Lung Cancer cell growth through other pathways but not the TP53 signaling pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	binding to both the N terminus and the C terminus of ESR1 (Georgescu 2005)
	interacting in a ligand-dependent manner with thyroid receptor alpha, retinoid X receptor alpha, and androgen receptor (Georgescu 2005)
	interacting in a ligand-independent manner with ESR2 and the retinoic acid receptor (Georgescu 2005)
	TRIM59, interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway
	TRIM59 interacts with TP53, promoting its ubiquitination and degradation, and might promote gastric carcinogenesis via this mechanism

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in human gastric tumors compared with nontumor tissues

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS