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FLASH GENE

Symbol

TRIM44

contributors: SGE/npt - updated : 15-06-2009

HGNC name	tripartite motif-containing 44
HGNC id	19016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p13      Physical location : 35.684.352 - 35.830.930
Synonym name	DIPB protein
Synonym symbol(s)	DIPB, MC7, HSA249128, MGC3490

DNA

TYPE	functioning gene
STRUCTURE	145.41 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 3182 isoform 1 38.3 344 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal RING zinc finger
	two B box domains type 1 and type 2, linked to
	a coiled-coil domain (RBCC), the so called tripartite motif (TRIM)

HOMOLOGY

interspecies	homolog to rattus Trim44 (92.7pc)
	homolog to murine Trim44 (92.4pc)

Homologene

FAMILY

RBCC (TRIM family)

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	inhibits ubiquitination of TRIM17 and thus stabilizes the protein (Urano 2009)
	may function as a new class of the "USP-like-TRIM" which regulates the activity of associated TRIM proteins (Urano 2009)
	may play a role in the procces of differenciation and maturation of neuronal cells

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	ions Zn2+

protein

interacting with TRIM17 (Urano 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS