Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRIM44 contributors: SGE/npt - updated : 15-06-2009
HGNC name tripartite motif-containing 44
HGNC id 19016
DNA
TYPE functioning gene
STRUCTURE 145.41 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3182 38.3 344 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RING zinc finger
  • two B box domains type 1 and type 2, linked to
  • a coiled-coil domain (RBCC), the so called tripartite motif (TRIM)
  • HOMOLOGY
    interspecies homolog to rattus Trim44 (92.7pc)
    homolog to murine Trim44 (92.4pc)
    Homologene
    FAMILY
  • RBCC (TRIM family)
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibits ubiquitination of TRIM17 and thus stabilizes the protein (Urano 2009)
  • may function as a new class of the "USP-like-TRIM" which regulates the activity of associated TRIM proteins (Urano 2009)
  • may play a role in the procces of differenciation and maturation of neuronal cells
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
  • protein
  • interacting with TRIM17 (Urano 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS