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FLASH GENE
Symbol TRIM26 contributors: mct - updated : 02-12-2013
HGNC name tripartite motif-containing 26
HGNC id 12962
Location 6p21.33      Physical location : 1.392.423 - 30.181.153
Synonym name
  • acid finger protein
  • RING finger protein 95
  • zinc finger protein 173
  • widely expressed acid zinc finger protein
    • Synonym symbol(s) ZNF173, AFP, RNF95, HCG-VI
    DNA
    TYPE functioning gene
    STRUCTURE 29.04 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S464 - D6S306 - TRIM26 - D6S273 - D6S1615 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3617 62 539 - 2001 11331580
    9 - 3451 - 539 - 2001 11331580
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • a B box domain
  • a coiled-coil domain
  • a C-terminal B30-2/SPRY domain
    • HOMOLOGY
    interspecies homolog to rattus Trim26 (87.8 pc)
    homolog to murine Trim26 (88.9 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • C3HC4 subfamily
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic bodies
    basic FUNCTION
  • functions in the immune response
  • TRIM26 promotes Hepatic stellate cells (HSCs) ferroptosis to suppress liver fibrosis through mediating the ubiquitination of SLC7A11
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • KDM6B-targeting of PHF20 for ubiquitination and degradation via recruitment of an E3 ligase, TRIM26
  • TRIM26 physically interacted with solute carrier family-7 member-11 (SLC7A11), a critical protein for lipid reactive oxygen species (ROS) scavenging, and mediated its ubiquitination
    • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    TRIM26-targeted SLC7A11 suppression can be a novel therapeutic strategy for liver fibrosis
    ANIMAL & CELL MODELS