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FLASH GENE

Symbol

TRIB2

contributors: mct/pgu - updated : 24-04-2017

HGNC name	tribbles homolog 2 (Drosophila)
HGNC id	30809

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p24.3      Physical location : 12.856.997 - 12.882.856
Synonym symbol(s)	TRB2, GS3955, C5FW, FLJ57420

DNA

TYPE	functioning gene
STRUCTURE	25.86 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021643 3 - 4408 NP_067675 - 343 - 1997 9342215

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Nervous brain       highly Reproductive male system testis     highly Respiratory respiratory tract trachea     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three distinct domains, a proline-rich N-terminus
	a serine/threonine kinase homology domain, kinase domain is essential for its function
	variant catalytic loop sequences compared to conventional kinases that are necessary for its activity
	a C-terminal COP1 binding domain

HOMOLOGY

interspecies	homolog to murine Trib2 (98.3pc)
	homolog to rattus Trib2 (98.0pc)

Homologene

FAMILY	protein kinase superfamily
	CAMK Ser/Thr protein kinase family
	Tribbles subfamily

CATEGORY

regulatory , antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	interacting with MAPK kinases and regulating activation of map kinases
	uveitis-associated candidate autoantigen
	potent novel regulator of monocyte biology, controlling the activation of these cells
	regulate gene expression by modulation of protein kinase signaling pathways
	regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression
	repressor of FOXO transcription factors, that contributes to the malignant phenotype of melanoma cells
	can bind both COP1 and CEBPA, leading to degradation of CEBPA
	potential driver of lung tumorigenesis through a mechanism that involves downregulation of CEBPA

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding partner and a negative regulator of selected MAPKs
	can bind both RFWD2 and CEBPA, leading to degradation of CEBPA
	TRIB2 associated-BTRC, RFWD2 and SMURF1 reduced TCF4/CTNNB1 expression, and these effects could be enhanced by TRIB2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in acute myelogenous leukemia tumoral     --over   in primary human lung tumors and in non-small cell lung cancer cells

Susceptibility

to multiple sclerosis

Variant & Polymorphism other	increasing the risk of multiple sclerosis

Candidate gene
Marker
Therapy target	may be a promising therapeutic target upon RNAi-mediated TRIB2 knockdown
	System Type Disorder Pubmed cancer     functional regions that are essential to its oncogenic role provide the basis for developing inhibitors that will block TRIB functions in cancer cancer     may be a promising therapeutic target upon RNAi-mediated TRIB2 knockdown cancer hemopathy   represent useful therapeutic targets for the treatment of AML in patients with dys-regulated trb activity

ANIMAL & CELL MODELS