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FLASH GENE

Symbol

TRHDE

contributors: mct - updated : 25-08-2008

HGNC name	thyrotropin-releasing hormone degrading enzyme
HGNC id	30748

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q15-q21      Physical location : 72.666.528 - 73.059.421
Synonym name	TRH-degrading ectoenzyme
	TRH (thyrotropin releasing hormone)
	pyroglutamyl-peptidase
	thyroliberinase
Synonym symbol(s)	PGPEP2, TRH-DE, PAP-II, FLJ22381
EC.number	3.4.19.6

DNA

TYPE	functioning gene
STRUCTURE	393.00 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TRHDE 19 - 5666 117 1024 - Clark (2003)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Respiratory respiratory tract trachea     highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracellular C terminal domain
	HEXXH+E motif, characteristic of a zinc dependent aminopeptidase

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

peptidase M1 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein type II

basic FUNCTION

involved in specific inactivation of TRH after its release

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

thyroid

a component	protein constituent of membrane
	homodimer, disulfide-linked

INTERACTION

DNA

RNA

small molecule
	binds 1 zinc ion per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS