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FLASH GENE
Symbol TRHDE contributors: mct - updated : 25-08-2008
HGNC name thyrotropin-releasing hormone degrading enzyme
HGNC id 30748
Location 12q15-q21      Physical location : 72.666.528 - 73.059.421
Synonym name
  • TRH-degrading ectoenzyme
  • TRH (thyrotropin releasing hormone)
  • pyroglutamyl-peptidase
  • thyroliberinase
  • Synonym symbol(s) PGPEP2, TRH-DE, PAP-II, FLJ22381
    EC.number 3.4.19.6
    DNA
    TYPE functioning gene
    STRUCTURE 393.00 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5666 117 1024 - Clark (2003)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular C terminal domain
  • HEXXH+E motif, characteristic of a zinc dependent aminopeptidase
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase M1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein type II
    basic FUNCTION
  • involved in specific inactivation of TRH after its release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
  • protein constituent of membrane
  • homodimer, disulfide-linked
  • INTERACTION
    DNA
    RNA
    small molecule
    binds 1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS