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FLASH GENE
Symbol TOE1 contributors: mct - updated : 19-10-2017
HGNC name target of EGR1, member 1 (nuclear)
HGNC id 15954
Location 1p34.1      Physical location : 45.805.341 - 45.809.649
Synonym symbol(s) FLJ13949, hCaf1z, PCH7
DNA
TYPE functioning gene
STRUCTURE 4.31 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2408 - 510 - 2009 19508870
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousspinal cord    
Reproductivefemale systemuterus   
 female systemplacenta  highly
 male systemtestis   
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C3H1-type zinc finger
  • a possible nuclear localization signal
  • a poly(A)-specific deadenylation nuclease region
  • HOMOLOGY
    interspecies homolog to rattus Toe1 (83.7pc)
    homolog to murine Toe1 (81.8pc)
    Homologene
    FAMILY
  • CAF1 family ribonuclease
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • cell growth inhibitor activity, altering the cell cycle through the up-regulation of p21 gene and pausing the cells in the G2/M phase
  • may have a tumor supressor role
  • acting as a co-regulator of TP53 (Sperandio 2009)
  • induces CDKN1A expression as well as TGF-beta expression
  • mediates the inhibitory growth effect of EGR1
  • displays a functional deadenylation domain and has been shown to participate in spliceosome assembly
  • PARN and TOE1 are nuclear granule-associated deadenylases, whose mutations are linked to multiple human diseases
  • PARN and TOE1 function redundantly in the biogenesis of telomerase RNA component (TERC), which shares sequence motifs found in H/ACA box scaRNAs
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • is able to bind TP53 and enhance the transcriptional activity of TP53-dependent gene targets
  • nuclear protein localized primarily in nucleoli and Cajal bodies that was identified as a downstream target of the immediate early gene EGR1
  • can be secreted by activated CD8(+) T lymphocytes and can be cleaved by the serine protease granzyme B, one of the main components of cytotoxic granules
  • cell & other
    REGULATION
    activated by EGR1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS