basic FUNCTION
| cell growth inhibitor activity, altering the cell cycle through the up-regulation of p21 gene and pausing the cells in the G2/M phase |
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may have a tumor supressor role |
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acting as a co-regulator of TP53 (Sperandio 2009) |
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induces CDKN1A expression as well as TGF-beta expression |
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mediates the inhibitory growth effect of EGR1 |
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displays a functional deadenylation domain and has been shown to participate in spliceosome assembly |
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PARN and TOE1 are nuclear granule-associated deadenylases, whose mutations are linked to multiple human diseases |
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PARN and TOE1 function redundantly in the biogenesis of telomerase RNA component (TERC), which shares sequence motifs found in H/ACA box scaRNAs |