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FLASH GENE
Symbol TOE1 contributors: mct - updated : 19-10-2017
HGNC name target of EGR1, member 1 (nuclear)
HGNC id 15954
Location 1p34.1      Physical location : 45.805.341 - 45.809.649
Synonym symbol(s) FLJ13949, hCaf1z, PCH7
DNA
TYPE functioning gene
STRUCTURE 4.31 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ10597 1p34.1 hypothetical protein FLJ10597 FLJ22353 1p34.1 hypothetical protein FLJ22353 LOC339541 1p34.1 hypothetical LOC339541 LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626 PTCH2 1p32.3-p32.1 patched homolog 2 (Drosophila) EIF2B3 1p34.1 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa LOC128192 1p34.1 similar to peptidyl-Pro cis trans isomerase FLJ21156 1p34.1 hypothetical protein FLJ21156 UROD 1p34 uroporphyrinogen decarboxylase ZSWIM5 1p34.1 zinc finger, SWIM domain containing 5 MGC15668 1p34.1 hypothetical protein MGC15668 MUTYH 1p34.3-p32.1 mutY homolog (E. coli) TOE1  target of EGR1, member 1 (nuclear) TESK2 1p32 testis-specific kinase 2 LOC126661 1p34.1 hypothetical protein LOC126661 DKFZP564I122 1p34.1 DKFZP564I122 protein PRDX1 1p34.1 peroxiredoxin 1 AKR1A1 1p33-p32 aldo-keto reductase family 1, member A1 (aldehyde reductase) NASP 1p34.1 nuclear autoantigenic sperm protein (histone-binding) FLJ33084 1p34.1 hypothetical protein FLJ33084 SP192 1p34.1 hypothetical protein SP192 LOC51249 1p34.1 hypothetical protein LOC51249 IPP 1p34-p32 intracisternal A particle-promoted polypeptide MAST205 1p33 intracisternal A particle-promoted polypeptide PIK3R3 1p34.1 phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) LOC388627 1 LOC388627 TSPAN-1 1p34.1 tetraspan 1 FLJ20277 RAD54L 1p32 RAD54-like (S. cerevisiae)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2408 - 510 - 2009 19508870
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousspinal cord    
Reproductivefemale systemuterus   
 female systemplacenta  highly
 male systemtestis   
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C3H1-type zinc finger
  • a possible nuclear localization signal
  • a poly(A)-specific deadenylation nuclease region
  • HOMOLOGY
    interspecies homolog to rattus Toe1 (83.7pc)
    homolog to murine Toe1 (81.8pc)
    Homologene
    FAMILY
  • CAF1 family ribonuclease
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • cell growth inhibitor activity, altering the cell cycle through the up-regulation of p21 gene and pausing the cells in the G2/M phase
  • may have a tumor supressor role
  • acting as a co-regulator of TP53 (Sperandio 2009)
  • induces CDKN1A expression as well as TGF-beta expression
  • mediates the inhibitory growth effect of EGR1
  • displays a functional deadenylation domain and has been shown to participate in spliceosome assembly
  • PARN and TOE1 are nuclear granule-associated deadenylases, whose mutations are linked to multiple human diseases
  • PARN and TOE1 function redundantly in the biogenesis of telomerase RNA component (TERC), which shares sequence motifs found in H/ACA box scaRNAs
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • is able to bind TP53 and enhance the transcriptional activity of TP53-dependent gene targets
  • nuclear protein localized primarily in nucleoli and Cajal bodies that was identified as a downstream target of the immediate early gene EGR1
  • can be secreted by activated CD8(+) T lymphocytes and can be cleaved by the serine protease granzyme B, one of the main components of cytotoxic granules
  • cell & other
    REGULATION
    activated by EGR1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS