Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TOE1 contributors: mct - updated : 19-10-2017
HGNC name target of EGR1, member 1 (nuclear)
HGNC id 15954
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C3H1-type zinc finger
  • a possible nuclear localization signal
  • a poly(A)-specific deadenylation nuclease region
    • HOMOLOGY
    interspecies homolog to rattus Toe1 (83.7pc)
    homolog to murine Toe1 (81.8pc)
    Homologene
    FAMILY
  • CAF1 family ribonuclease
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • cell growth inhibitor activity, altering the cell cycle through the up-regulation of p21 gene and pausing the cells in the G2/M phase
  • may have a tumor supressor role
  • acting as a co-regulator of TP53 (Sperandio 2009)
  • induces CDKN1A expression as well as TGF-beta expression
  • mediates the inhibitory growth effect of EGR1
  • displays a functional deadenylation domain and has been shown to participate in spliceosome assembly
  • PARN and TOE1 are nuclear granule-associated deadenylases, whose mutations are linked to multiple human diseases
  • PARN and TOE1 function redundantly in the biogenesis of telomerase RNA component (TERC), which shares sequence motifs found in H/ACA box scaRNAs
    • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • is able to bind TP53 and enhance the transcriptional activity of TP53-dependent gene targets
  • nuclear protein localized primarily in nucleoli and Cajal bodies that was identified as a downstream target of the immediate early gene EGR1
  • can be secreted by activated CD8(+) T lymphocytes and can be cleaved by the serine protease granzyme B, one of the main components of cytotoxic granules
    • cell & other
    REGULATION
    activated by EGR1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS