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FLASH GENE
Symbol TNXB contributors: mct - updated : 27-09-2011
HGNC name tenascin XB
HGNC id 11976
Corresponding disease
EDSL1 Ehlers-Danlos-like syndrome, type 1
VUR8 vesicoureteral reflux 8
Location 6p21.3      Physical location : 3.261.779 - 32.077.151
Synonym name hexabrachion-like
Synonym symbol(s) TNXB2, TNXB1, TENX, HXBT, XBS, TNX
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping, gene in gene
text overlapping CREBL1 by its 5' end and CYP21A2 by its 3' end
STRUCTURE 68.22 kb     45 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • three transcriptionnal start sites
  • sp1 and sp3 binding sites
  • MAPPING cloned Y linked N status provisional
    Map pter - HLA-B - LTA - TNF - C2 C2 - CFB - RDBP - SKIV2L - DOM3Z - STK19 - C4A C4A - [CYP21A1P /TNXA ] - STK19P - C4B C4B - (CYP21A2 CYP21A2 /TNXB /CREBL1 ) - cen
    Authors Bristow (94), Shen (94), Dangel (95), Tee (95)
    Text [including YA transcript], (including YB transcript)
    Physical map
    BAT5 6p21.33 HLA-B associated transcript 5 LY6G6D 6p21.3 lymphocyte antigen 6 complex, locus G6D LY6G6E 6p21.3 lymphocyte antigen 6 complex, locus G6E LY6G6C 6p21.3 lymphocyte antigen 6 complex, locus G6C C6orf25 6p21.3 chromosome 6 open reading frame 25 DDAH2 6p21.3 dimethylarginine dimethylaminohydrolase 2 CLIC1 6p21.3 chloride intracellular channel 1 MSH5 6p21.3 mutS homolog 5 (E. coli) C6orf27 6p21.31 chromosome 6 open reading frame 27 VARS2 6p21.3 valyl-tRNA synthetase 2 LSM2 6p21.3 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) HSPA1L 6p21.3 heat shock 70kDa protein 1-like HSPA1A 6p21.3 heat shock 70kDa protein 1A HSPA1B 6p21.3 heat shock 70kDa protein 1B C6orf48 6p21.3 chromosome 6 open reading frame 48 NEU1 6p21.3 sialidase 1 (lysosomal sialidase) C6orf29 6p21.3 chromosome 6 open reading frame 29 BAT8 6p21.31 HLA-B associated transcript 8 C6orf46 6p21.31 chromosome 6 open reading frame 46 C2 6p21.3 complement component 2 BF 6p21.3 B-factor, properdin RDBP 6p21.33 RD RNA binding protein SKIV2L 6p21.3 superkiller viralicidic activity 2-like (S. cerevisiae) DOM3Z 6p21.3 dom-3 homolog Z (C. elegans) STK19 6p21.3 serine/threonine kinase 19 C4B 6p21.3 complement component 4B CYP21A2 6p21.3 cytochrome P450, family 21, subfamily A, polypeptide 2 TNXB 6p21.3 tenascin XB CREBL1 6p21.3 cAMP responsive element binding protein-like 1 FKBPL 6p21.3 FK506 binding protein like C6orf31 6p21.1 chromosome 6 open reading frame 31 PPT2 6p21.3 palmitoyl-protein thioesterase 2 EGFL8 6p21.31 EGF-like-domain, multiple 8 AGPAT1 6p21.3 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) RNF5 6p21.31 ring finger protein 5 AGER 6p21.3 advanced glycosylation end product-specific receptor PBX2 6p21.3 pre-B-cell leukemia transcription factor 2 C6orf9 6p21.3 chromosome 6 open reading frame 9 NOTCH4 6p21.3 Notch homolog 4 (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    44 - 13143 464 4289 - 1996 8923003
    XB isoform 1
    13 - 3143 - 673 only adrenal gland 1996 8923003
  • exon 33-45
  • XB isoform 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     stomach   highly
    Endocrineadrenal glandcortex  highly
    Nervousbrain     Homo sapiens
    Reproductivemale systemprostate   
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text adrenal, testis, skeletal and smooth muscle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nineteen Egf-like motifs
  • thirty four fibronectin type III-like domains
  • a fibrinogen-like domain
  • HOMOLOGY
    interspecies homolog to murine Tnxb
    intraspecies homolog to CYP21A2
    Homologene
    FAMILY tenascin family of glycoproteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • extracellular matrix glycoprotein
  • TNXB and KIF11 proteins were co-localized in the cytoplasm in interphase and mitosis, but TNXB did not localize on mitotic spindle microtubules, on which KIF11 prominently localized in mitosis
  • basic FUNCTION
  • playing a role in interactions between cell and ECM, antiadhesive effect, inhibiting cell migration, and in maintaining homeostasis of the extracellular matrix
  • via trimerization and multiple interactions with components of collagenous fibrils, can play a crucial role in the organisation of extracellular matrices
  • role in supporting the growth of epithelial tumors
  • unlikely involved in matrix deposition in the early phase of wound healing, but required in the later phase when remodeling and maturation of the matrix establishes and improves its biomechanical properties
  • potentially having a role in the pathogenesis of disorders in the CNS
  • possible involvement of TNXB in the function of KIF11
  • might be directly involved in determining the mechanical properties of collagen-rich tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EDSL1 , VUR8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant mesothelioma compared with ovarian/peritoneal serous carcinoma
    Susceptibility
  • to rheumatoid arthritis
  • to systemic lupus erythematosus
  • Variant & Polymorphism SNP increasing the risk of systemic lupus erythematosus
    Candidate gene
    Marker
  • may be a new diagnostic marker of malignant mesothelioma in the differential diagnosis of cancers involving the serosal cavities, particularly in the differential diagnosis between this tumor and ovarian/peritoneal serous carcinoma
  • Therapy target
    ANIMAL & CELL MODELS