Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TNXB

contributors: mct - updated : 27-09-2011

HGNC name	tenascin XB
HGNC id	11976

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	EDSL1 Ehlers-Danlos-like syndrome, type 1 VUR8 vesicoureteral reflux 8
Location	6p21.3      Physical location : 3.261.779 - 32.077.151
Synonym name	hexabrachion-like
Synonym symbol(s)	TNXB2, TNXB1, TENX, HXBT, XBS, TNX

DNA

TYPE	functioning gene
SPECIAL FEATURE	overlapping, gene in gene
text	overlapping CREBL1 by its 5' end and CYP21A2 by its 3' end
STRUCTURE	68.22 kb     45 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	three transcriptionnal start sites
	sp1 and sp3 binding sites

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - HLA-B - LTA - TNF - C2 C2 - CFB - RDBP - SKIV2L - DOM3Z - STK19 - C4A C4A - [CYP21A1P /TNXA ] - STK19P - C4B C4B - (CYP21A2 CYP21A2 /TNXB /CREBL1 ) - cen
Authors	Bristow (94), Shen (94), Dangel (95), Tee (95)
Text	[including YA transcript], (including YB transcript)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_019105 44 - 13143 464 4289 - 1996 8923003 XB isoform 1 NM_032470 13 - 3143 - 673 only adrenal gland 1996 8923003 exon 33-45 XB isoform 2

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   stomach       highly Endocrine adrenal gland cortex     highly Nervous brain         Homo sapiens Reproductive male system prostate       Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	adrenal, testis, skeletal and smooth muscle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nineteen Egf-like motifs
	thirty four fibronectin type III-like domains
	a fibrinogen-like domain

HOMOLOGY

interspecies

homolog to murine Tnxb

intraspecies

homolog to CYP21A2

Homologene

FAMILY

tenascin family of glycoproteins

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
text	extracellular matrix glycoprotein
	TNXB and KIF11 proteins were co-localized in the cytoplasm in interphase and mitosis, but TNXB did not localize on mitotic spindle microtubules, on which KIF11 prominently localized in mitosis

basic FUNCTION	playing a role in interactions between cell and ECM, antiadhesive effect, inhibiting cell migration, and in maintaining homeostasis of the extracellular matrix
	via trimerization and multiple interactions with components of collagenous fibrils, can play a crucial role in the organisation of extracellular matrices
	role in supporting the growth of epithelial tumors
	unlikely involved in matrix deposition in the early phase of wound healing, but required in the later phase when remodeling and maturation of the matrix establishes and improves its biomechanical properties
	potentially having a role in the pathogenesis of disorders in the CNS
	possible involvement of TNXB in the function of KIF11
	might be directly involved in determining the mechanical properties of collagen-rich tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EDSL1 , VUR8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in malignant mesothelioma compared with ovarian/peritoneal serous carcinoma

Susceptibility

to rheumatoid arthritis to systemic lupus erythematosus

Variant & Polymorphism SNP	increasing the risk of systemic lupus erythematosus

Candidate gene
Marker	may be a new diagnostic marker of malignant mesothelioma in the differential diagnosis of cancers involving the serosal cavities, particularly in the differential diagnosis between this tumor and ovarian/peritoneal serous carcinoma
Therapy target

ANIMAL & CELL MODELS