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FLASH GENE

Symbol

TNS4

contributors: mct/ - updated : 28-08-2015

HGNC name	tensin 4
HGNC id	24352

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.2      Physical location : 38.632.081 - 38.657.854
Synonym name	C-terminal tensin-like
Synonym symbol(s)	CTEN, FLJ14950, PP14434

DNA

TYPE	functioning gene
STRUCTURE	25.77 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032865 13 - 4090 NP_116254 - 715 - 2002 12154022

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately   mouth tongue     predominantly Reproductive female system placenta     moderately   female system uterus     highly Respiratory respiratory tract larynx     moderately Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six potential tyrosine phosphorylation sites
	an Src homology (SH) 2 and a phosphotyrosine-binding (PTB) domain that allows it to interact with the cytoplasmic tail of the beta-integrins
	two independent focal adhesion binding sites
	C-terminal tandem SH2-PTB domain pairing

HOMOLOGY

Homologene

FAMILY

tensin family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	localization at focal adhesions and/or in the cytoplasm; in addition, has been detected in the nucleus

basic FUNCTION	involved in intracellular signaling cascade
	thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
	large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
	focal adhesion protein that play important roles in signal transduction and cytoskeletal reorganization
	role of the TNS4-STAT3 axis in epithelial sheet invasion and tubulogenesis
	in the colon and pancreas, is a downstream target of KRAS and may be a mechanism through which KRAS regulates of cell motility
	oncogenic role in pancreatic cancer through promotion of colony formation and cell motility
	function for TNS4 in prolonging signaling from EGFR by reducing its ligand-induced degradation
	nuclear TNS4 contributes likely to cancer cell proliferation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	regulation of the Rho-GAP activity of DLC1 by TNS3 and TNS4 controls EGF-driven cell migration and transformation
	regulates EGFR protein levels through a posttranslational mechanism
	TNS4 recruits signaling molecules, such as DLC1, to focal adhesions, modulates homeostasis of receptor tyrosine kinases, including EGFR and MET, and promotes cell migration
	nuclear exporting of TNS4 is a XPO1-dependent process

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   or nul in prostate cancers and prostate cancer cell lines tumoral     --over   in 70 p100 of pancreatic cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	its expression is of prognostic significance in colorectal cancer, delineating a TNS4-ILK pathway controlling cell motility and possibly promoting metastasis
Therapy target
	System Type Disorder Pubmed cancer metastases   anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors

ANIMAL & CELL MODELS