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FLASH GENE
Symbol TNS4 contributors: mct/ - updated : 28-08-2013
HGNC name tensin 4
HGNC id 24352
Location 17q21.2      Physical location : 38.632.081 - 38.657.854
Synonym name C-terminal tensin-like
Synonym symbol(s) CTEN, FLJ14950, PP14434
DNA
TYPE functioning gene
STRUCTURE 25.77 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 4090 - 715 - 2002 12154022
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 mouthtongue  predominantly
Reproductivefemale systemplacenta  moderately
 female systemuterus  highly
Respiratoryrespiratory tractlarynx  moderately
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six potential tyrosine phosphorylation sites
  • an Src homology (SH) 2 and a phosphotyrosine-binding (PTB) domain that allows it to interact with the cytoplasmic tail of the beta-integrins
  • C-terminal tandem SH2-PTB domain pairing
  • HOMOLOGY
    Homologene
    FAMILY
  • tensin family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in intracellular signaling cascade
  • thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
  • large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
  • focal adhesion protein that play important roles in signal transduction and cytoskeletal reorganization
  • role of the TNS4-STAT3 axis in epithelial sheet invasion and tubulogenesis
  • in the colon and pancreas, is a downstream target of KRAS and may be a mechanism through which KRAS regulates of cell motility
  • oncogenic role in pancreatic cancer through promotion of colony formation and cell motility
  • function for TNS4 in prolonging signaling from EGFR by reducing its ligand-induced degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulation of the Rho-GAP activity of DLC1 by TNS3 and TNS4 controls EGF-driven cell migration and transformation
  • regulates EGFR protein levels through a posttranslational mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    or nul in prostate cancers and prostate cancer cell lines
    tumoral     --over  
    in 70 p100 of pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • its expression is of prognostic significance in colorectal cancer, delineating a TNS4-ILK pathway controlling cell motility and possibly promoting metastasis
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS