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FLASH GENE

Symbol

TNNI3K

contributors: mct - updated : 30-08-2010

HGNC name	TNNI3 interacting kinase
HGNC id	19661

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p31.1      Physical location : 74.663.946 - 75.010.108
Synonym name	cardiac ankyrin repeat kinase
Synonym symbol(s)	CARK

DNA

TYPE	functioning gene
STRUCTURE	346.22 kb     25 Exon(s)

regulatory sequence	Promoter
	Binding site
text structure	MEF2 binding region is the most critical cis-acting element in the promoter, and TNNI3K transcription level can be down-regulated by MEF2C antisense (Wang 2008)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015978 25 - 3001 92.9 835 - Feng (2007) NM_001112808 - - 3269 - 936 - Feng (2007)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Reproductive male system testis       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven N-terminal ankyrin (ANK) repeats, necessary for autophosphorylation
	a protein kinase domain
	a C-terminal Ser-rich domain, functional region that negatively regulates the kinase activity (Feng 2007)

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	in the nucleus of cardiac myocytes

basic FUNCTION	cardiac-specific kinase playing an important role in cardiac system
	exhibits dual-specific kinase activity and forms dimers or oligomers that may be necessary for its activation (Feng 2007)
	improved cardiac function by enhancing beating frequency and increasing the contractile force and epinephrine response of spontaneous action potentials without an increase of the single-cell size (Lai 2008)
	promotes cardiomyogenesis, enhances cardiac performance, and protects the myocardium from ischemic injury by suppressing p38/JNK-mediated apoptosis (Lai 2008)
	may be involved in the development of cardiac hypertrophy (Lai 2009)
	plays a critical role in the modulation of different forms of heart disease, and this protein may provide a novel target for therapeutic intervention (Wheeler 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with cardiac troponin I
	interaction between TNNI3K and PRDX3 (Feng 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   may promote cardiac myogenesis, improve cardiac performance, and attenuate ischemia-induced ventricular remodeling (Lai 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	modulation of TNNI3K activity would be a useful therapeutic approach for ischemic cardiac disease (Lai 2008)

ANIMAL & CELL MODELS