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FLASH GENE
Symbol TNNI3K contributors: mct - updated : 30-08-2010
HGNC name TNNI3 interacting kinase
HGNC id 19661
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven N-terminal ankyrin (ANK) repeats, necessary for autophosphorylation
  • a protein kinase domain
  • a C-terminal Ser-rich domain, functional region that negatively regulates the kinase activity (Feng 2007)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text in the nucleus of cardiac myocytes
    basic FUNCTION
  • cardiac-specific kinase playing an important role in cardiac system
  • exhibits dual-specific kinase activity and forms dimers or oligomers that may be necessary for its activation (Feng 2007)
  • improved cardiac function by enhancing beating frequency and increasing the contractile force and epinephrine response of spontaneous action potentials without an increase of the single-cell size (Lai 2008)
  • promotes cardiomyogenesis, enhances cardiac performance, and protects the myocardium from ischemic injury by suppressing p38/JNK-mediated apoptosis (Lai 2008)
  • may be involved in the development of cardiac hypertrophy (Lai 2009)
  • plays a critical role in the modulation of different forms of heart disease, and this protein may provide a novel target for therapeutic intervention (Wheeler 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with cardiac troponin I
  • interaction between TNNI3K and PRDX3 (Feng 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may promote cardiac myogenesis, improve cardiac performance, and attenuate ischemia-induced ventricular remodeling (Lai 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • modulation of TNNI3K activity would be a useful therapeutic approach for ischemic cardiac disease (Lai 2008)
    • ANIMAL & CELL MODELS