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FLASH GENE
Symbol TNFSF13 contributors: mct - updated : 19-01-2017
HGNC name tumor necrosis factor (ligand) superfamily, member 13
HGNC id 11928
Location 17p13.1      Physical location : 7.461.608 - 7.464.925
Synonym name
  • TNF- and APOL-related leukocyte expressed ligand 2
  • a proliferation-inducing ligand
  • tumor necrosis factor (ligand) superfamily member 13 transcript variant delta
  • TNF-related death ligand 1
  • CD256 antigen
    • Synonym symbol(s) APRIL, TALL2, TN13, CD256, TRDL-1, UNQ383/PRO715, ZTNF2
    DNA
    TYPE functioning gene
    STRUCTURE 3.32 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2293 27.4 250 - 2000 10706119
    variant alpha
    5 - 2245 - 234 - 2000 10706119
    variant beta
    7 - 2112 - 247 - 2000 10706119
    variant gamma
    5 - 2212 - 223 - 2000 10706119
    variant delta
    6 - 1517 - 205 - 2000 10706119
    variant eta
    5 - 2209 - 222 - 2000 10706119
    variant zeta
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinelarge intestinecolon highly
    Nervousbrainlimbic systemhippocampus highly Mus musculusFetal
    Reproductivefemale systemovary  highly
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage Homo sapiens
    Nervouspyramidal cell Mus musculusFetal
    not specificsynoviocyte Homo sapiens
    cell lineage
    cell lines
  • highly in transformed cell lines (cancer of colon, thyroid)
  • malignant glioma cell lines
    • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • 28AA cytoplasmic domain
  • hydrophobic TM region
  • extracellular domain of 201 amino acids with no signal peptide
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfsf13
    Homologene
    FAMILY
  • tumor necrosis factor (ligand) superfamily (TNFSF)
    • CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text type 2 membrane protein
    basic FUNCTION
  • putative regulator of tumor cell growth
  • a proliferation-inducing ligand
  • involved in the regulation of death-ligand-induced apoptotic signaling in malignat glioma cells
  • TNFSF13, TNFSF13B are known to be involved in the occurrence of autoimmune diseases
  • regulator of B-cell-mediated immune responses through the modulation of B-cell survival and activation
  • macrophages express a membrane-bound form of TNFSF13 which, upon stimulation, modulates the activities of macrophages through stimulation or inhibition of processes associated with inflammation
  • TNFSF13, TNFSF13B are members of the TNF superfamily that regulate B-cell survival and autoreactivity
  • TNFSF13, TNFSF13B induced rapid phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and AKT1 kinases and promoted an increase in human adipose-derived stem cells (hASC) proliferation, without affecting the immunosuppressive capacity of these cells
  • TNFSF13, TNFSF13B play a crucial role in B cell development, survival, and antibody production
  • is a negative regulator of collagen-induced arthritis (CIA) by regulating autoantibody production
  • promotes axon elongation by a mechanism that depends both on ERK signaling and PI3-kinase/AKT1/GSK3B signaling
  • TNFSF13 and FDX1 have potential roles in IgA nephropathy (IgAN)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterotrimer with ANP32B
  • TNFSF13, TNFSF13B assemble as homotrimers that bind and activate several receptors that they partially share
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFSF13 binding to TNFRSF17 decreases cell proliferation by inducing G(2)/M cell cycle arrest
  • NFKB1 mediates TNFSF13-induced HOXC4 transcription
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in autoimmune disease
    constitutional     --over  
    in monocytes and T cells significantly higher in multiple sclerosis
    constitutional     --over  
    with TNF, TNFSF13B, TNFSF13 in Behcet disease
    constitutional     --over  
    in inflammatory skin lesions of psoriasis
    tumoral     --over  
    in skin squamous cell carcinomas
    tumoral     --over  
    correlates with poor prognosis in clear cell renal cell carcinoma
    tumoral     --over  
    in breast carcinoma tissue lesions
    constitutional     --over  
    in systemic lupus erythematosus (SLE)
    tumoral     --over  
    IRF8 and TNFSF13 expression was significantly higher in lymphomas with IGH rearrangements targeting these loci
    Susceptibility to atrial fibrillation
    Variant & Polymorphism SNP
  • rs11552708 [G/A (G67R)]of TNFSF13 associated with atrial fibrillation
    • Candidate gene
    Marker
  • may be an important marker of disease activity in patients with SLE
  • TNFSF13, TNFSF13B might be useful markers for predicting disease activity in IgG4-related disease
    • Therapy target
    ANIMAL & CELL MODELS