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FLASH GENE
Symbol TNFRSF25 contributors: mct/pgu - updated : 04-12-2012
HGNC name tumor necrosis factor receptor superfamily, member 25
HGNC id 11910
Location 1p36.31      Physical location : 6.521.220 - 6.526.255
Synonym name
  • tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
  • death domain receptor 3 soluble form
  • lymphocyte associated receptor of death
  • death receptor beta
  • apoptosis inducing receptor
  • apoptosis-mediating receptor
  • translocating chain-association membrane protein
  • WSL-1 protein
  • Synonym symbol(s) DR3, LARD, TRAMP, TNFRSF12, APO-3, TR3, DDR3, WSL1, WSL-LR
    DNA
    TYPE functioning gene
    STRUCTURE 5.04 kb     10 Exon(s)    2 Copie(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure duplicated approximatively 200kb upstream the original gene, the duplication is more prevalent in patients with rhumatoid arthritis
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC126772 1p36.31 similar to erythrocyte membrane-associated giant protein antigen 332 NPHP4 1p36.22 nephronophthisis 4 LOC388590 1 LOC388590 KCNAB2 1p36.3 potassium voltage-gated channel, shaker-related subfamily, beta member 2 CHD5 1p36.23 chromodomain helicase DNA binding protein 5 RPL22 1p36.3-p36.2 ribosomal protein L22 LOC388591 1 hypothetical gene supported by AK128246 FLJ32096 1p36.23 hypothetical protein FLJ32096 ICMT 1p36.21 isoprenylcysteine carboxyl methyltransferase MGC40168 1p36.23 hypothetical protein MGC40168 LOC390992 1 similar to helix-loop-helix transcription factor GPR153  G protein-coupled receptor 153 BACH 1p36.2 G protein-coupled receptor 153 LOC388592 1 similar to Transcription factor HES-2 (Hairy and enhancer of split 2) ESPN 1p36.31-p36.11 espin TNFRSF25 1p36.2 tumor necrosis factor receptor superfamily, member 25 KIAA0720 1p36.23 tumor necrosis factor receptor superfamily, member 25 FLJ23323 1p36.23 hypothetical protein FLJ23323 TAS1R1 1p36.23 taste receptor, type 1, member 1 HKR3 1p36.31 GLI-Kruppel family member HKR3 KIAA0469 1p36.23 KIAA0469 gene product PHF13 1p36.23 PHD finger protein 13 MGC33488 1p36.23 hypothetical protein MGC33488 FLJ10737 1p36.23 hypothetical protein FLJ10737 CAMTA1 1p36.31-p36.23 calmodulin binding transcription activator 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1665 43.4 426 - 1997 9114039
    membrane protein
    10 - 1638 42.9 417 - 1997 9114039
  • shorter and distinct internal region
  • membrane protein
  • 9 - 1527 38.7 380 - 1997 9114039
  • frameshift
  • secreted protein
  • 9 - 1503 37.9 372 - 1997 9114039
  • frameshift
  • secreted protein
  • 5 - 1089 22.9 234 - 1997 9114039
  • lacking an intermal region
  • secreted protein
  • - - 894 16.9 181 - 1997 9114039
    secreted protein
    - - 1669 - 426 lymphoid cell lines non Hodgkin lymphome 1997 9114039
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Digestiveintestinelarge intestinecolon  
    Reproductivemale systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    Lymphoid/Immunelymphocyte
    Skeletonosteoblast
    cell lineage
    cell lines lymphoid T cell and immature B cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four extracytoplasmic cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a cytoplasmic tail with the DEATH domain
  • an extracellular domain with four homologous cysteine-rich domains (CRDs)
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION
    text several secreted isoforms
    basic FUNCTION
  • inducing NFKB acitivation and apoptosis when overexpressed
  • involved in the regulation of apoptosis in neuroblastoma and primitive neuroectodermal tumors
  • may play a role in lymphocyte homeostasis
  • may be involved in the removal of self-reactive T cells in the thymus
  • has an essential role in the development of allergic lung inflammation
  • potential inducible mediator of tubular inflammation and injury
  • involved in atherosclerosis via the induction of proinflammatory cytokines/chemokines and decreasing plaque stability by inducing extracellular matrix degrading enzymes
  • can mediate apoptosis in osteoblasts
  • TNFSF15 and TNFRSF25 may play an important role in the pathophysiological process of the aged bladder
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BAG4
  • interacts strongly via the death domains of TNFRSF1
  • TNFSF15-TNFRSF25 interactions are necessary and sufficient for T cell-dependent inflammatory bowel disease
  • TRADD is essential for TNFSF15/TNFRSF25 signaling
  • costimulates T-cell activation, but it is unique among these receptors in that it signals through an intracytoplasmic death domain and the adapter protein TRADD (TNFR-associated death domain)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma cell lines
    tumoral     --over  
    in primitive neuroectodermal tumors with good prognosis
    Susceptibility
  • to rheumatoid arthritis
  • increased in term placentas from women with pregnancies complicated by preeclampsia
  • up-regulated in renal tubular epithelial cells and endothelial cells of some interlobular arteries during acute transplant rejection
  • Variant & Polymorphism other D158G mutation increasing the risk of rheumatoid arthritis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    proatherogenic role for both TNFSF15 and TNFRSF25 that implicates this pathway as a target for the therapeutic intervention of atherosclerosis
    ANIMAL & CELL MODELS