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FLASH GENE
Symbol TNFRSF25 contributors: mct/pgu - updated : 04-12-2012
HGNC name tumor necrosis factor receptor superfamily, member 25
HGNC id 11910
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in neuroblastoma cell lines
tumoral     --over  
in primitive neuroectodermal tumors with good prognosis
Susceptibility
  • to rheumatoid arthritis
  • increased in term placentas from women with pregnancies complicated by preeclampsia
  • up-regulated in renal tubular epithelial cells and endothelial cells of some interlobular arteries during acute transplant rejection
  • Variant & Polymorphism other D158G mutation increasing the risk of rheumatoid arthritis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    proatherogenic role for both TNFSF15 and TNFRSF25 that implicates this pathway as a target for the therapeutic intervention of atherosclerosis
    ANIMAL & CELL MODELS