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Symbol TNFRSF10A contributors: mct - updated : 07-01-2011
HGNC name tumor necrosis factor receptor superfamily, member 10a
HGNC id 11904
Location 8p21.3      Physical location : 23.048.970 - 23.082.680
Synonym name
  • cytotoxic TRAIL receptor
  • death receptor 4
  • TNF-related apoptosis inducing ligand receptor 1
  • CD261 antigen
  • Synonym symbol(s) TRAILR1, DR4, APO2, TRAILR-1, CD261, MGC9365
    TYPE functioning gene
    STRUCTURE 33.71 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • several putative binding sites for transcription factors including activator protein 1 (AP-1)
  • GLI3 binding sites (GLI3 binds to the promoter and Hedgehog requires an intact GLI3-repression activity to silence TNFRSF10A expression)
  • MAPPING cloned Y linked   status confirmed
    Physical map
    PHYHIP 8p21.2 phytanoyl-CoA hydroxylase interacting protein POLR3D 8q21 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa PIWIL2 8p21.2 piwi-like 2 (Drosophila) SLC39A14 8p21.2 solute carrier family 39 (zinc transporter), member 14 PPP3CC 8p21.2 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) LOC389639 8 LOC389639 SCAM-1 8p21.2 vinexin beta (SH3-containing adaptor molecule-1) PDLIM2 8p21.2 PDZ and LIM domain 2 (mystique) DBC-1 8p22 p30 DBC protein BIN3 8p21.2 bridging integrator 3 FLJ14107 8p21.2 hypothetical protein FLJ14107 EGR3 8p23-p21 early growth response 3 MGC22776 8p21.2 hypothetical protein MGC22776 RHOBTB2 8p21.2 Rho-related BTB domain containing 2 TNFRSF10B 8p21 tumor necrosis factor receptor superfamily, member 10b LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2 LYSAL1 8p22-p21.3 lysosomal apyrase-like 1 MSCP 8p21.2 mitochondrial solute carrier protein PRO1496 8p21.2 hypothetical protein PRO1496 LOC389642 8 LOC389642 NKX3-1 8p21 NK3 transcription factor related, locus 1 (Drosophila) LOC137814 8p21.2 similar to homeobox protein NKX2-6 STC1 8p21-p11.2 stanniocalcin 1
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1764 50 468 - 1997 9325248
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemovary  highly
     male systemprostate  moderately
    Respiratoryrespiratory tracttrachea  predominantly
    cell lineage
    cell lines
    at STAGE
  • a putative signal peptide
  • three extracellular cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail with the DEATH domain
  • conjugated GlycoP , PhosphoP
    mono polymer homomer , trimer
    intraspecies homolog to TNF
  • tumor necrosis factor receptor superfamily
  • CATEGORY tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • inducing a caspase-dependent apoptotic pathway
  • acting as a receptor for the cytotoxic ligand TNFSF10
  • promoting the activation of NF-kappa-B
  • with TNFSF10 and TNFRSF10B, play an important role in inflammation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    signaling signal transduction
    a component
    small molecule
  • interacting with TRADD and RIP
  • binding to APO2L
  • TNK2 is an essential player in the spatial regulation of TNFSR10A, TNFSR10B (PMId: 24085293)
  • cell & other
    induced by TP53 inducible
    alpha-tocopheryl succinate (alpha-TOS) in a p53-dependent manner
    repressed by HH (silencing by HH requires an intact GLI3 activity)
    Other regulated by TNFRSF10A
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in nasopharyngeal cancer
    Susceptibility to cancer
    Variant & Polymorphism SNP
  • A683C with tumor specific allele distribution
  • A1322G G allele and A683C C allele are associated with increased risk for cancer
  • Candidate gene
    Therapy target
  • cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis