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FLASH GENE

Symbol

TNFRSF10A

contributors: mct - updated : 07-01-2015

HGNC name	tumor necrosis factor receptor superfamily, member 10a
HGNC id	11904

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p21.3      Physical location : 23.048.970 - 23.082.680
Synonym name	cytotoxic TRAIL receptor
	death receptor 4
	TNF-related apoptosis inducing ligand receptor 1
	CD261 antigen
Synonym symbol(s)	TRAILR1, DR4, APO2, TRAILR-1, CD261, MGC9365

DNA

TYPE	functioning gene
STRUCTURE	33.71 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   transcription factor
text structure	several putative binding sites for transcription factors including activator protein 1 (AP-1)
	GLI3 binding sites (GLI3 binds to the promoter and Hedgehog requires an intact GLI3-repression activity to silence TNFRSF10A expression)

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003844 10 - 1764 NP_003835 50 468 - 1997 9325248

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       moderately Reproductive female system ovary     highly   male system prostate     moderately Respiratory respiratory tract trachea     predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative signal peptide
	three extracellular cysteine-rich pseudorepeats typical for TNFR superfamily
	a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
	a small cytoplasmic tail with the DEATH domain

conjugated

GlycoP , PhosphoP

mono polymer

homomer , trimer

HOMOLOGY

intraspecies

homolog to TNF

Homologene

FAMILY

tumor necrosis factor receptor superfamily

CATEGORY

tumor suppressor , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane protein

basic FUNCTION	inducing a caspase-dependent apoptotic pathway
	acting as a receptor for the cytotoxic ligand TNFSF10
	promoting the activation of NF-kappa-B
	with TNFSF10 and TNFRSF10B, play an important role in inflammation

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with TRADD and RIP
	binding to APO2L
	endogenous MARCHF8 regulates the steady-state cell surface expression of TNFRS10A
	TNK2 is an essential player in the spatial regulation of TNFSR10A, TNFSR10B
	DDIT3 and KAT2A cooperatively up-regulate TNFRSF10A and TNFRSF10B

cell & other

REGULATION

induced by	TP53 inducible
		alpha-tocopheryl succinate (alpha-TOS) in a p53-dependent manner

repressed by

HH (silencing by HH requires an intact GLI3 activity)

Other	regulated by TNFRSF10B
	only pro-apoptotic signaling through TNFRSF10A and TNFRSF10B has been found to be regulated by N- and O-glycosylation, respectively

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in nasopharyngeal cancer

Susceptibility

to cancer

Variant & Polymorphism SNP	A683C with tumor specific allele distribution
	A1322G G allele and A683C C allele are associated with increased risk for cancer

Candidate gene
Marker
Therapy target	cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis

ANIMAL & CELL MODELS