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FLASH GENE
Symbol TNFRSF10A contributors: mct - updated : 07-01-2011
HGNC name tumor necrosis factor receptor superfamily, member 10a
HGNC id 11904
Location 8p21.3      Physical location : 23.048.970 - 23.082.680
Synonym name
  • cytotoxic TRAIL receptor
  • death receptor 4
  • TNF-related apoptosis inducing ligand receptor 1
  • CD261 antigen
  • Synonym symbol(s) TRAILR1, DR4, APO2, TRAILR-1, CD261, MGC9365
    DNA
    TYPE functioning gene
    STRUCTURE 33.71 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • several putative binding sites for transcription factors including activator protein 1 (AP-1)
  • GLI3 binding sites (GLI3 binds to the promoter and Hedgehog requires an intact GLI3-repression activity to silence TNFRSF10A expression)
  • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1764 50 468 - 1997 9325248
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemovary  highly
     male systemprostate  moderately
    Respiratoryrespiratory tracttrachea  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative signal peptide
  • three extracellular cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail with the DEATH domain
  • conjugated GlycoP , PhosphoP
    mono polymer homomer , trimer
    HOMOLOGY
    intraspecies homolog to TNF
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • inducing a caspase-dependent apoptotic pathway
  • acting as a receptor for the cytotoxic ligand TNFSF10
  • promoting the activation of NF-kappa-B
  • with TNFSF10 and TNFRSF10B, play an important role in inflammation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRADD and RIP
  • binding to APO2L
  • TNK2 is an essential player in the spatial regulation of TNFSR10A, TNFSR10B (PMId: 24085293)
  • cell & other
    REGULATION
    induced by TP53 inducible
    alpha-tocopheryl succinate (alpha-TOS) in a p53-dependent manner
    repressed by HH (silencing by HH requires an intact GLI3 activity)
    Other regulated by TNFRSF10A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in nasopharyngeal cancer
    Susceptibility to cancer
    Variant & Polymorphism SNP
  • A683C with tumor specific allele distribution
  • A1322G G allele and A683C C allele are associated with increased risk for cancer
  • Candidate gene
    Marker
    Therapy target
  • cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis
  • ANIMAL & CELL MODELS