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FLASH GENE
Symbol TNFRSF10A contributors: mct - updated : 07-01-2015
HGNC name tumor necrosis factor receptor superfamily, member 10a
HGNC id 11904
Location 8p21.3      Physical location : 23.048.970 - 23.082.680
Synonym name
  • cytotoxic TRAIL receptor
  • death receptor 4
  • TNF-related apoptosis inducing ligand receptor 1
  • CD261 antigen
  • Synonym symbol(s) TRAILR1, DR4, APO2, TRAILR-1, CD261, MGC9365
    DNA
    TYPE functioning gene
    STRUCTURE 33.71 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • several putative binding sites for transcription factors including activator protein 1 (AP-1)
  • GLI3 binding sites (GLI3 binds to the promoter and Hedgehog requires an intact GLI3-repression activity to silence TNFRSF10A expression)
  • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1764 50 468 - 1997 9325248
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemovary  highly
     male systemprostate  moderately
    Respiratoryrespiratory tracttrachea  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative signal peptide
  • three extracellular cysteine-rich pseudorepeats typical for TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic tail with the DEATH domain
  • conjugated GlycoP , PhosphoP
    mono polymer homomer , trimer
    HOMOLOGY
    intraspecies homolog to TNF
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • inducing a caspase-dependent apoptotic pathway
  • acting as a receptor for the cytotoxic ligand TNFSF10
  • promoting the activation of NF-kappa-B
  • with TNFSF10 and TNFRSF10B, play an important role in inflammation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRADD and RIP
  • binding to APO2L
  • TNK2 is an essential player in the spatial regulation of TNFSR10A, TNFSR10B
  • DDIT3 and KAT2A cooperatively up-regulate TNFRSF10A and TNFRSF10B
  • cell & other
    REGULATION
    induced by TP53 inducible
    alpha-tocopheryl succinate (alpha-TOS) in a p53-dependent manner
    repressed by HH (silencing by HH requires an intact GLI3 activity)
    Other regulated by TNFRSF10B
    only pro-apoptotic signaling through TNFRSF10A and TNFRSF10B has been found to be regulated by N- and O-glycosylation, respectively
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in nasopharyngeal cancer
    Susceptibility to cancer
    Variant & Polymorphism SNP
  • A683C with tumor specific allele distribution
  • A1322G G allele and A683C C allele are associated with increased risk for cancer
  • Candidate gene
    Marker
    Therapy target
  • cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis
  • ANIMAL & CELL MODELS