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FLASH GENE
Symbol TNFAIP1 contributors: mct/npt/pgu - updated : 15-03-2016
HGNC name tumor necrosis factor, alpha-induced protein 1 (endothelial)
HGNC id 11894
Location 17q11.2      Physical location : 26.662.547 - 26.674.033
Synonym name
  • protein B12
  • BTB/POZ domain-containing Adaptor for CUL3-mediated RHOA Degradation family member 2
  • Synonym symbol(s) B12, B61, EDP1, MGC2317, Bacurd2, BTBD34
    DNA
    TYPE functioning gene
    STRUCTURE 11.49 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • one functional Sp1-binding site within the human TNFAIP1 core promoter region, and Sp1 is supposed to be involved in the elevation of TNFAIP1 in response to TNF induction, and thus participate in inflammation-associated angiogenesis
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC390782 17 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) NLK 17q11.2 nemo-like kinase PYY2 17q11.1-q11.2 peptide YY, 2 (seminalplasmin) PPY2 17q11.1-q11.2 pancreatic polypeptide 2 LOC339274 17q11.2 similar to Hypothetical protein KIAA0563 FLJ40504 17q11.2 hypothetical protein FLJ40504 MAC30 17q11.2 hypothetical protein FLJ40504 LOC90410 17q11.2 intraflagellar transport protein IFT20 TNFAIP1 17q11 tumor necrosis factor, alpha-induced protein 1 (endothelial) PDIP38 MGC45714 17q11.2 hypothetical protein MGC45714 VTN 17q11.2 vitronectin (serum spreading factor, somatomedin B, complement S-protein) SARM1 17q11 sterile alpha and TIR motif containing 1 MGC9564 17q11.2 similar to RIKEN cDNA 1110002C08 gene LOC388363 17 similar to 40S ribosomal protein S7 (S8) SLC13A2 17p11.1-q11.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 FOXN1 17q11.2 forkhead box N1 UNC119 17q11.2 unc-119 homolog (C. elegans) PIGS 17p13.2 phosphatidylinositol glycan, class S ALDOC 17q11.2 aldolase C, fructose-bisphosphate SPAG5 17q11.1 sperm associated antigen 5 FLJ25006 17q11.2 hypothetical protein FLJ25006 KIAA0100 17q11.2 KIAA0100 gene product SDF2 17q11.2 stromal cell-derived factor 2 SUPT6H 17q11.2 suppressor of Ty 6 homolog (S. cerevisiae) MGC39650 17q11.2 hypothetical protein MGC39650 RAB34 17q11.1 RAB34, member RAS oncogene family RPL23A 17q11 ribosomal protein L23a LOC116238 17q11.2 hypothetical protein BC014072 NEK8 17q11.1 NIMA (never in mitosis gene a)- related kinase 8 TRAF4 17q11-q12 TNF receptor-associated factor 4 FLJ10700 17q11.2 hypothetical protein FLJ10700
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3822 - 316 - 1992 1370465
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselscapillary   
    Digestiveliver   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningendothelium  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BTB(POZ) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may play roles in the DNA repair, DNA synthesis, cell apoptosis
  • may be involved in the process of cancer
  • may function in DNA replication, apoptosis and human diseases
  • KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CSNK2B could phosphorylate TNFAIP1, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA)
  • TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins
  • CREB1 is a negative regulator of the TNFAIP1 gene
  • KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons
  • cell & other
    REGULATION
    induced by TNF in umbilical vein endothelial cells
    TNF-alpha, interleukin-1 beta and lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    can accelerate the apoptosis of HeLa cell
    tumoral     --over  
    significantly increased in osteosarcoma tissues compared with that in adjacent non-cancerous tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    TNFAIP1 may act as a potential therapeutic target for the treatment of cancer
    ANIMAL & CELL MODELS