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FLASH GENE
Symbol TNFAIP1 contributors: mct/npt/pgu - updated : 15-03-2016
HGNC name tumor necrosis factor, alpha-induced protein 1 (endothelial)
HGNC id 11894
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BTB(POZ) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may play roles in the DNA repair, DNA synthesis, cell apoptosis
  • may be involved in the process of cancer
  • may function in DNA replication, apoptosis and human diseases
  • KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CSNK2B could phosphorylate TNFAIP1, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA)
  • TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins
  • CREB1 is a negative regulator of the TNFAIP1 gene
  • KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons
  • cell & other
    REGULATION
    induced by TNF in umbilical vein endothelial cells
    TNF-alpha, interleukin-1 beta and lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    can accelerate the apoptosis of HeLa cell
    tumoral     --over  
    significantly increased in osteosarcoma tissues compared with that in adjacent non-cancerous tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    TNFAIP1 may act as a potential therapeutic target for the treatment of cancer
    ANIMAL & CELL MODELS