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FLASH GENE
Symbol TLX1 contributors: mct - updated : 10-11-2010
HGNC name T-cell leukemia homeobox 1
HGNC id 5056
Corresponding disease
TCL3 T-cell acute lymphoblastic leukemia (T-ALL) 3
Location 10q24.31      Physical location : 102.891.060 - 102.897.545
Synonym name
  • homeo box 11 (T-cell lymphoma 3-associated breakpoint)
  • T-cell leukemia, homeobox 1
  • proto-oncogene TCL-3
  • homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
  • homeobox protein Hox-11
  • Synonym symbol(s) MGC163402, TCL3, HOX11
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text oriented in a head-to-head manner with TD1
    STRUCTURE 6.49 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SCD 10q23-q24 stearoyl-CoA desaturase (delta-9-desaturase) LOC90271 10q24.31 hypothetical protein LOC90271 WNT8B 10q24 wingless-type MMTV integration site family, member 8B SEC31L2 10q24.32 SEC31-like 2 (S. cerevisiae) NDUFB8 10q23.2-q23.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa HIF1AN 10q24 hypoxia-inducible factor 1, alpha subunit inhibitor PAX2 10q22.1-q24.3 paired box gene 2 C10orf6 10q24.31 chromosome 10 open reading frame 6 SEMA4G 10q24.2 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G MRPL43 10q24.1-q24.3 mitochondrial ribosomal protein L43 PEO1 KIAA1813 10q24 KIAA1813 protein FLJ23209 10q24.32 hypothetical protein FLJ23209 BA108L7.2 10q24.32 similar to rat tricarboxylate carrier-like protein FKSG28 10q24.32 hypothetical protein FKSG28 C10orf1 10q24 chromosome 10 open reading frame 1 TLX1 10q24 T-cell leukemia, homeobox 1 LBX1 10q24 transcription factor similar to D. melanogaster homeodomain protein lady bird late BTRC 10q24-q25 beta-transducin repeat containing POLL 10q23 polymerase (DNA directed), lambda DKFZP566F084 SHFM3 10q24 split hand/foot malformation (ectrodactyly) type 3 FGF8 10q24 fibroblast growth factor 8 (androgen-induced) NPM3 10q24.31 nucleophosmin/nucleoplasmin, 3 MGEA5 10q24.1-q24.3 meningioma expressed antigen 5 (hyaluronidase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2123 34.2 330 - 2009 19250647
    - - 2146 - 257 - 2009 19250647
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     stomach    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in embryonic cells destined for the pancreas, salivary glands, tongue, cranial nerves and cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain
  • an Eh1-like motif, essential for optimal transcriptional activation of two TLX1 target genes, ALDH1A1 and FHL1
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential for the survival of splenic precursors during organogenesis
  • involved in transcriptional deregulation of G1/S growth-control genes, mediated in large part through blockade of PP1/PP2A phosphatase activity
  • TLX1-mediated differentiation arrest may be achieved in part through a mechanism that involves redirection of CREBBP and/or its sequestration in repressive chromatin domains
  • NK-like homeodomain transcription factor that is both normally required for embryonic development and aberrantly expressed in T-cell acute lymphoblastic leukemia
  • having a dual function regulator whose activity in respect to FHL1 is critically dependent upon its cellular concentration, as well as cell type and promoter context
  • homeodomain transcription factor involved in splenogenesis and neuron formation
  • TLX1-mediated target gene activation can occur in part via derepression strategies involving Gro/TLE corepressors
  • directly downregulates the expression of CHEK1 and additional mitotic control genes and induces loss of the mitotic checkpoint in nontransformed preleukemic thymocytes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the ubiquitous transcription factor CTF1 and PBX homeodomains proteins
  • interaction with SMARCD3, NR4A3, NFKB2
  • can regulate target genes including ALDH1A1 and FHL1
  • interacts with TLE1 via an Eh1-like motif
  • interacting with SIX2, HOXA2 (loss-of-function of TLX1 leads to loss of SIX2 expression and loss-of-function of HOXA2 leads to expanded SIX2 expression)
  • TLX1 and NOTCH1 synergistically regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of MYC
  • co-operation between TLX1 and MEIS1, MEIS2 proteins may have a significant role in T-cell leukemogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TCL3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    and fused with TCRD in acute lymphoblastic leukemia
    tumoral       gain of function
    in T-acute lymphoblastic leukemia with t(10;14) (q24;q11), or t(7;10) (q35;q24), or t(5;14) (q35;q32)
    tumoral     --over  
    in acute lymphoblastic leukemia with good outlook
    tumoral     --other  
    inappropriately expressed in a major subgroup of T cell acute lymphoblastic leukemia (T-ALL) where it is strongly associated with activating NOTCH1 mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS