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Symbol TLX1 contributors: mct - updated : 10-11-2010
HGNC name T-cell leukemia homeobox 1
HGNC id 5056
Corresponding disease
TCL3 T-cell acute lymphoblastic leukemia (T-ALL) 3
Location 10q24.31      Physical location : 102.891.060 - 102.897.545
Synonym name
  • homeo box 11 (T-cell lymphoma 3-associated breakpoint)
  • T-cell leukemia, homeobox 1
  • proto-oncogene TCL-3
  • homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
  • homeobox protein Hox-11
  • Synonym symbol(s) MGC163402, TCL3, HOX11
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text oriented in a head-to-head manner with TD1
    STRUCTURE 6.49 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SCD 10q23-q24 stearoyl-CoA desaturase (delta-9-desaturase) LOC90271 10q24.31 hypothetical protein LOC90271 WNT8B 10q24 wingless-type MMTV integration site family, member 8B SEC31L2 10q24.32 SEC31-like 2 (S. cerevisiae) NDUFB8 10q23.2-q23.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa HIF1AN 10q24 hypoxia-inducible factor 1, alpha subunit inhibitor PAX2 10q22.1-q24.3 paired box gene 2 C10orf6 10q24.31 chromosome 10 open reading frame 6 SEMA4G 10q24.2 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G MRPL43 10q24.1-q24.3 mitochondrial ribosomal protein L43 PEO1 KIAA1813 10q24 KIAA1813 protein FLJ23209 10q24.32 hypothetical protein FLJ23209 BA108L7.2 10q24.32 similar to rat tricarboxylate carrier-like protein FKSG28 10q24.32 hypothetical protein FKSG28 C10orf1 10q24 chromosome 10 open reading frame 1 TLX1 10q24 T-cell leukemia, homeobox 1 LBX1 10q24 transcription factor similar to D. melanogaster homeodomain protein lady bird late BTRC 10q24-q25 beta-transducin repeat containing POLL 10q23 polymerase (DNA directed), lambda DKFZP566F084 SHFM3 10q24 split hand/foot malformation (ectrodactyly) type 3 FGF8 10q24 fibroblast growth factor 8 (androgen-induced) NPM3 10q24.31 nucleophosmin/nucleoplasmin, 3 MGEA5 10q24.1-q24.3 meningioma expressed antigen 5 (hyaluronidase)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2123 34.2 330 - 2009 19250647
    - - 2146 - 257 - 2009 19250647
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
    physiological period embryo
    Text in embryonic cells destined for the pancreas, salivary glands, tongue, cranial nerves and cochlea
  • helix-turn-helix, DNA binding domain
  • an Eh1-like motif, essential for optimal transcriptional activation of two TLX1 target genes, ALDH1A1 and FHL1
    CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • essential for the survival of splenic precursors during organogenesis
  • involved in transcriptional deregulation of G1/S growth-control genes, mediated in large part through blockade of PP1/PP2A phosphatase activity
  • TLX1-mediated differentiation arrest may be achieved in part through a mechanism that involves redirection of CREBBP and/or its sequestration in repressive chromatin domains
  • NK-like homeodomain transcription factor that is both normally required for embryonic development and aberrantly expressed in T-cell acute lymphoblastic leukemia
  • having a dual function regulator whose activity in respect to FHL1 is critically dependent upon its cellular concentration, as well as cell type and promoter context
  • homeodomain transcription factor involved in splenogenesis and neuron formation
  • TLX1-mediated target gene activation can occur in part via derepression strategies involving Gro/TLE corepressors
  • directly downregulates the expression of CHEK1 and additional mitotic control genes and induces loss of the mitotic checkpoint in nontransformed preleukemic thymocytes
  • CELLULAR PROCESS nucleotide, transcription
    a component
    small molecule
  • interacting with the ubiquitous transcription factor CTF1 and PBX homeodomains proteins
  • interaction with SMARCD3, NR4A3, NFKB2
  • can regulate target genes including ALDH1A1 and FHL1
  • interacts with TLE1 via an Eh1-like motif
  • interacting with SIX2, HOXA2 (loss-of-function of TLX1 leads to loss of SIX2 expression and loss-of-function of HOXA2 leads to expanded SIX2 expression)
  • TLX1 and NOTCH1 synergistically regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of MYC
  • co-operation between TLX1 and MEIS1, MEIS2 proteins may have a significant role in T-cell leukemogenesis
  • cell & other
    corresponding disease(s) TCL3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    and fused with TCRD in acute lymphoblastic leukemia
    tumoral       gain of function
    in T-acute lymphoblastic leukemia with t(10;14) (q24;q11), or t(7;10) (q35;q24), or t(5;14) (q35;q32)
    tumoral     --over  
    in acute lymphoblastic leukemia with good outlook
    tumoral     --other  
    inappropriately expressed in a major subgroup of T cell acute lymphoblastic leukemia (T-ALL) where it is strongly associated with activating NOTCH1 mutations
    Variant & Polymorphism
    Candidate gene
    Therapy target